Selective lesion of the hippocampus increases the differentiation of immature neurons in the monkey amygdala.

Details

Serval ID
serval:BIB_94D40A609D4A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Selective lesion of the hippocampus increases the differentiation of immature neurons in the monkey amygdala.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Chareyron L.J., Amaral D.G., Lavenex P.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
13/12/2016
Peer-reviewed
Oui
Volume
113
Number
50
Pages
14420-14425
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
A large population of immature neurons is present in the ventromedial portion of the adult primate amygdala, a region that receives substantial direct projections from the hippocampal formation. Here, we show the effects of neonatal (n = 8) and adult (n = 6) hippocampal lesions on the populations of mature and immature neurons in the paralaminar, lateral, and basal nuclei of the adult monkey amygdala. Compared with unoperated controls (n = 7), the number of mature neurons was about 70% higher in the paralaminar nucleus of neonate- and adult-lesioned monkeys, and 40% higher in the lateral and basal nuclei of neonate-lesioned monkeys. The number of immature neurons in the paralaminar nucleus was 40% higher in neonate-lesioned monkeys and 30% lower in adult-lesioned monkeys. Similar changes in neuron numbers were also found in two monkeys with nonexperimental, selective, bilateral hippocampal damage. These changes in neuron numbers following hippocampal lesions appear to reflect the differentiation of immature neurons present in the paralaminar nucleus. After adult lesions, the differentiation of immature neurons was essentially restricted to the paralaminar nucleus and was associated with a decrease in the population of immature neurons. In contrast, after neonatal lesions, the differentiation of immature neurons involved the paralaminar, lateral, and basal nuclei. It was associated with an increase in the population of immature neurons in the paralaminar nucleus. Such lesion-induced neuronal plasticity sheds new light on potential mechanisms that may facilitate functional recovery following focal brain injury.

Keywords
Amygdala/pathology, Amygdala/physiopathology, Animals, Animals, Newborn, Cell Count, Cell Differentiation, Cell Movement, Female, Hippocampus/injuries, Hippocampus/pathology, Hippocampus/physiopathology, Macaca mulatta, Male, Neural Stem Cells/pathology, Neural Stem Cells/physiology, Neuronal Plasticity, Neurons/pathology, Neurons/physiology, immature neuron, migration, neurodevelopmental disorders, plasticity, subventricular zone
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2017 20:05
Last modification date
08/05/2019 22:15
Usage data