Topiramate for smoking cessation

Details

Serval ID
serval:BIB_94C8FB55AD1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Topiramate for smoking cessation
Journal
Psychiatry and Clinical Neurosciences
Author(s)
Khazaal  Y., Cornuz  J., Bilancioni  R., Zullino  D. F.
ISSN
1323-1316 (Print)
Publication state
Published
Issued date
06/2006
Volume
60
Number
3
Pages
384-8
Notes
Clinical Trial, Phase I
Journal Article --- Old month value: Jun
Abstract
Due to its AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)/kainate antagonism, topiramate would be particularly interesting in addiction treatment. Flexible-dose topiramate was prescribed to 13 smokers (10 smokers who wanted to stop smoking, and three who received topiramate for other reasons). Six out of 13 smokers were abstinent at 2 months and two more subjects had reduced their cigarette consumption by >50%. With one exception, temporary reduction of the number of smoked cigarettes preceded definitive abstinence at month 2. Three more subjects who achieved a momentary reduction had, however, to interrupt the treatment due to intolerable side-effects. Controlled trials are needed to confirm these preliminary observations.
Keywords
Adult Behavior, Addictive/*drug therapy Female Fructose/*analogs & derivatives/therapeutic use Humans Male Middle Aged Neuroprotective Agents/*therapeutic use Pilot Projects Receptors, AMPA Smoking/*prevention & control *Smoking Cessation alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/agonists
Pubmed
Web of science
Create date
25/01/2008 14:42
Last modification date
20/08/2019 15:57
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