The tumor microenvironment and its contribution to tumor evolution toward metastasis.

Details

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_94A8FAABFFB6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The tumor microenvironment and its contribution to tumor evolution toward metastasis.
Journal
Histochemistry and Cell Biology
Author(s)
Lorusso G., Rüegg C.
ISSN
0948-6143 (Print)
ISSN-L
0948-6143
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
130
Number
6
Pages
1091-1103
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Cancer cells acquire cell-autonomous capacities to undergo limitless proliferation and survival through the activation of oncogenes and inactivation of tumor suppressor genes. Nevertheless, the formation of a clinically relevant tumor requires support from the surrounding normal stroma, also referred to as the tumor microenvironment. Carcinoma-associated fibroblasts, leukocytes, bone marrow-derived cells, blood and lymphatic vascular endothelial cells present within the tumor microenvironment contribute to tumor progression. Recent evidence indicates that the microenvironment provides essential cues to the maintenance of cancer stem cells/cancer initiating cells and to promote the seeding of cancer cells at metastatic sites. Furthermore, inflammatory cells and immunomodulatory mediators present in the tumor microenvironment polarize host immune response toward specific phenotypes impacting tumor progression. A growing number of studies demonstrate a positive correlation between angiogenesis, carcinoma-associated fibroblasts, and inflammatory infiltrating cells and poor outcome, thereby emphasizing the clinical relevance of the tumor microenvironment to aggressive tumor progression. Thus, the dynamic and reciprocal interactions between tumor cells and cells of the tumor microenvironment orchestrate events critical to tumor evolution toward metastasis, and many cellular and molecular elements of the microenvironment are emerging as attractive targets for therapeutic strategies.
Keywords
Angiogenesis Inhibitors/therapeutic use, Animals, Cell Proliferation, Cell Survival, Chemokines/metabolism, Cytokines/metabolism, Humans, Inflammation/pathology, Inflammation Mediators/metabolism, Neoplasm Metastasis, Neoplasms/blood supply, Neoplasms/drug therapy, Neoplastic Stem Cells/immunology, Neoplastic Stem Cells/pathology, Neovascularization, Pathologic/pathology, Stromal Cells/immunology, Stromal Cells/pathology
Pubmed
Web of science
Open Access
Yes
Create date
25/03/2009 18:52
Last modification date
25/09/2019 7:10
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