The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.

Details

Serval ID
serval:BIB_94227173F2D6
Type
Article: article from journal or magazin.
Collection
Publications
Title
The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.
Journal
Nature Communications
Author(s)
Lande R., Botti E., Jandus C., Dojcinovic D., Fanelli G., Conrad C., Chamilos G., Feldmeyer L., Marinari B., Chon S., Vence L., Riccieri V., Guillaume P., Navarini A.A., Romero P., Costanzo A., Piccolella E., Gilliet M., Frasca L.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
5
Pages
5621
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: epublish
Abstract
Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide. Psoriasis is considered to be an autoimmune disease, but the precise nature of the autoantigens triggering T-cell activation remains poorly understood. Here we find that two-thirds of patients with moderate-to-severe plaque psoriasis harbour CD4(+) and/or CD8(+) T cells specific for LL37, an antimicrobial peptide (AMP) overexpressed in psoriatic skin and reported to trigger activation of innate immune cells. LL37-specific T cells produce IFN-γ, and CD4(+) T cells also produce Th17 cytokines. LL37-specific T cells can infiltrate lesional skin and may be tracked in patients blood by tetramers staining. Presence of circulating LL37-specific T cells correlates significantly with disease activity, suggesting a contribution to disease pathogenesis. Thus, we uncover a role of LL37 as a T-cell autoantigen in psoriasis and provide evidence for a role of AMPs in both innate and adaptive immune cell activation.
Pubmed
Web of science
Open Access
Yes
Create date
16/01/2015 14:45
Last modification date
08/05/2019 22:12
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