Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_940B57CFCA8B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis.
Journal
PloS one
Author(s)
Ackermann D., Groessl M., Pruijm M., Ponte B., Escher G., d'Uscio C.H., Guessous I., Ehret G., Pechère-Bertschi A., Martin P.Y., Burnier M., Dick B., Vogt B., Bochud M., Rousson V., Dhayat N.A.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
14
Number
3
Pages
e0214549
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Urinary steroid metabolomics by GC-MS is an established method in both clinical and research settings to describe steroidogenic disorders. However, population-based reference intervals for adults do not exist.
We measured daytime and night time urinary excretion of 40 steroid metabolites by GC-MS in 1128 adult participants of European ancestry, aged 18 to 90 years, within a large population-based, multicentric, cross-sectional study. Age and sex-related patterns in adjacent daytime and night time urine collections over 24 hours were modelled for each steroid metabolite by multivariable linear mixed regression. We compared our results with those obtained through a systematic literature review on reference intervals of urinary steroid excretion.
Flexible models were created for all urinary steroid metabolites thereby estimating sex- and age-related changes of the urinary steroid metabolome. Most urinary steroid metabolites showed an age-dependence with the exception of 6β-OH-cortisol, 18-OH-cortisol, and β-cortol. Reference intervals for all metabolites excreted during 24 hours were derived from the 2.5th and 97.5th percentile of modelled reference curves. The excretion rate per period of metabolites predominantly derived from the adrenals was mainly higher during the day than at night and the correlation between day and night time metabolite excretion was highly positive for most androgens and moderately positive for glucocorticoids.
This study gives unprecedented new insights into sex- and age-specificity of the human adult steroid metabolome and provides further information on the day/night variation of urinary steroid hormone excretion. The population-based reference ranges for 40 GC-MS-measured metabolites will facilitate the interpretation of steroid profiles in clinical practice.
Pubmed
Web of science
Open Access
Yes
Create date
05/04/2019 11:26
Last modification date
20/08/2019 15:56
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