Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_940B3CBCD2E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice.
Journal
Plos One
Author(s)
Ziros P., Zagoriti Z., Lagoumintzis G., Kyriazopoulou V., Iskrenova R.P., Habeos E.I., Sykiotis G.P., Chartoumpekis D.V., Habeos I.G.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
11
Number
9
Pages
e0162024
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Fibroblast growth factor 21 (Fgf21) is a hormone with emerging beneficial roles in glucose and lipid homeostasis. The interest in Fgf21 as a potential antidiabetic drug and the factors that regulate its production and secretion is growing. Statins are the most widely prescribed drug for the treatment of dyslipidemia. However, the function of statins is not limited to the lowering of cholesterol as they are associated with pleiotropic actions such as antioxidant, anti-inflammatory and cytoprotective effects. The recently described effect of statins on mitochondrial function and the induction of Fgf21 by mitochondrial stress prompted us to investigate the effect of statin treatment on Fgf21 expression in the liver. To this end, C57BL6J male mice and primary mouse hepatocytes were treated with simvastatin, and Fgf21 expression was subsequently assessed by immunoblotting and quantitative real-time PCR. Hepatic Fgf21 protein and mRNA and circulating levels of FGF21significantly decreased in mice that had received simvastatin in their food (0.1% w/w) for 1 week. This effect was also observed with simvastatin doses as low as 0.01% w/w for 1 week or following 2 intraperitoneal injections within a single day. The reduction in Fgf21 mRNA levels was further verified in primary mouse hepatocytes, indicating that the effect of simvastatin is cell autonomous. In conclusion, simvastatin treatment reduced the circulating and hepatic Fgf21 levels and this effect warrants further investigation with reference to its role in metabolism.
Pubmed
Web of science
Open Access
Yes
Create date
21/10/2016 15:32
Last modification date
20/08/2019 15:56
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