Prevention of acute and chronic ascending pyelonephritis in rats by aminoglycoside antibiotics accumulated and persistent in kidneys
Details
Serval ID
serval:BIB_93BDA74A7F6F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevention of acute and chronic ascending pyelonephritis in rats by aminoglycoside antibiotics accumulated and persistent in kidneys
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
Publication state
Published
Issued date
03/1981
Peer-reviewed
Oui
Volume
19
Number
3
Pages
381-5
Notes
Journal Article --- Old month value: Mar
Abstract
Gentamicin, because it is stored in renal tissues, can prevent acute retrograde pyelonephritis. Since different aminoglycosides accumulate and persist to various degrees in the kidney parenchyma, the prophylactic activities of gentamicin, tobramycin, amikacin, and netilmicin were compared. The four antibiotics were given intramuscularly to rats 3 days before initiating ascending unilateral pyelonephritis with Escherichia coli. Despite different degrees of renal accumulation at the time of infection (tobramycin and amikacin accumulated significantly less), all four aminoglycosides displayed similar protection against ascending pyelonephritis. This protection was conferred in the absence of active antibiotic detectable in the urine and was therefore attributed to antibiotic stored in the renal parenchyma. Those animals that developed pyelonephritis despite aminoglycoside prophylaxis had less severe acute kidney infection and inflammation. This resulted 3 months later in an almost complete protection against renal scarring (chronic pyelonephritis). These results in rats suggest that renal accumulation and persistence of aminoglycosides may be used to advantage in the prophylaxis or in the treatment of kidney infections.
Keywords
Aminoglycosides/metabolism/therapeutic use
Animals
Anti-Bacterial Agents/metabolism/*therapeutic use
Kidney/*metabolism
Male
Pyelonephritis/pathology/*prevention & control
Rats
Pubmed
Web of science
Create date
11/02/2008 12:40
Last modification date
20/08/2019 14:56