Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_93BBF14FADEC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer.
Journal
British Journal of Cancer
Author(s)
Zeleniuch-Jacquotte A., Shore R.E., Afanasyeva Y., Lukanova A., Sieri S., Koenig K.L., Idahl A., Krogh V., Liu M., Ohlson N., Muti P., Arslan A.A., Lenner P., Berrino F., Hallmans G., Toniolo P., Lundin E.
ISSN
1532-1827 (Electronic)
ISSN-L
0007-0920
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
105
Number
9
Pages
1458-1464
Language
english
Abstract
Background:It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.Methods:We conducted a case-control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay.Results:Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI=1.3, 4.6; P(trend)=0.007) for 2-OHE1 and 1.9 (95% CI=1.1, 3.5; P(trend)=0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1 : 16α-OHE1 ratio.Conclusion:Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer.
Pubmed
Web of science
Open Access
Yes
Create date
30/09/2011 15:03
Last modification date
20/08/2019 15:56
Usage data