Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease

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Serval ID
serval:BIB_93B467D38952
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease
Journal
Biomolecular Concepts
Author(s)
Montagner A., Wahli W.
ISSN
1868-503X (Electronic)
ISSN-L
1868-5021
Publication state
Published
Issued date
2013
Volume
4
Number
1
Pages
53-64
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Among the three peroxisome proliferator-activated receptor (PPAR) transcription factors, PPARβ/δ is the isotype with the broadest expression pattern. In fact, the expression of PPARβ/δ is ubiquitous, albeit at levels that are tightly regulated. Herein, we reviewed its multiple functions in skin health and disease. PPARβ/δ has pro-differentiating effects in keratinocytes, regulates sebocyte differentiation, and promotes hair follicle growth in healthy skin. Furthermore, we reviewed novel insights into the roles of PPARβ/δ in skin wound healing, especially in inhibiting apoptosis and in modulating keratinocyte proliferation and migration. Therefore, PPARβ/δ represents a research target for the understanding and treatment of inflammatory skin diseases, such as psoriasis and acne vulgaris. In addition, PPARβ/δ is a tumor growth modifier. Epidemiological studies have established that tumor progression may be exacerbated by chronic low-grade inflammation, a condition promoting the production of the lipids that act as modulators of PPARβ/δ activity. The action of PPARβ/δ in skin cancer is ambivalent, which might be explained by this receptor's putative highly context-specific behavior, which depends on a combination of factors ranging from receptor expression levels to co-regulator distribution, diversity and activity of the ligands produced, and other tissue-specific conditions. Given its diverse and crucial roles in many tissues and organs, PPARβ/δ will remain a major focus of future research.
Keywords
PPAR delta/metabolism, PPAR-beta/metabolism, Skin/growth & development, Skin/metabolism, Skin/pathology, Skin Diseases/metabolism, Skin Diseases/pathology
Pubmed
Open Access
Yes
Create date
13/07/2018 10:00
Last modification date
01/10/2019 7:18
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