An index of 5-HT synthesis changes during early antidepressant treatment: α-[11C]methyl-l-tryptophan PET study

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State: Public
Version: author
Serval ID
serval:BIB_93A4825FC189
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
An index of 5-HT synthesis changes during early antidepressant treatment: α-[11C]methyl-l-tryptophan PET study
Journal
Neurochemistry International
Author(s)
Berney Alexandre, Nishikawa Masami, Benkelfat Chawki, Debonnel Guy, Gobbi Gabriella, Diksic Mirko
ISSN
1872-9754
ISSN-L
0197-0186
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
52
Number
4/5
Pages
701-708
Language
english
Abstract
The antidepressant selective serotonin transporter inhibitors (SSRIs) are clinically active after a delay of several weeks. Indeed, the rapid increase of serotonin (5-HT) caused by SSRIs, stimulates the 5-HT1A autoreceptors, which exert a negative feedback on the 5-HT neurotransmission. Only when autoreceptors are desensitized, can SSRIs exert their therapeutic activity. The 5-HT1A receptor antagonist pindolol has been used to accelerate the clinical effects of antidepressant by preventing the negative feedback. Using the a-[11C]methyl-L-tryptophan/positron emission tomography (PET), the goal of the present double-blind, randomized study was to compare the changes in a-[11C]methyl-L-tryptophan trapping, an index of serotonin synthesis, in patients suffering from unipolar depression treated with the SSRI citalopram (20 mg/day) plus placebo versus patients treated with citalopram plus pindol (7.5 mg/day). PET and Hamilton depression rating scale (HDRS-17) were performed at baseline, and after 10 and 24 days of antidepressant treatment. Results show that the combination citalopram plus pindol, compared to citalopram alone shows a more rapid and greater increase of an index of 5-HT synthesis in prefrontal cortex (BA 9). This research is the first human PET study demonstrating that, after 24 days, the combination SSRIs plus pindolol produces a greater increase of the metabolism of serotonin in the prefrontal cortex, an area associated to depressive symptoms.
Keywords
Tracer imaging , Citalopram , Pindolol , Placebo , Human depression
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11/01/2013 10:29
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20/08/2019 15:56
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