New-onset obesity after liver transplantation-outcomes and risk factors: the Swiss Transplant Cohort Study.

Details

Serval ID
serval:BIB_939EA1F073F3
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
New-onset obesity after liver transplantation-outcomes and risk factors: the Swiss Transplant Cohort Study.
Journal
Transplant international
Author(s)
Beckmann S., Denhaerynck K., Stampf S., Saigi-Morgui N., Binet I., Koller M., Boely E., De Geest S.
Working group(s)
Psychosocial Interest Group, Swiss Transplant Cohort Study
Contributor(s)
Helmy R., Leppla L., Luta X., Mauthner O., Struker M., Boehler A., Gerull S., Berben L., Huynh-Do U., Catana E., Seiler A., Klaghofer R., Künzler-Heule P., Burkhalter H., Achermann R., Amico P., Aubert J.D., Banz V., Beldi G., Benden C., Berger C., Bochud P.Y., Bucher H., Carell T., Catana E., Chalandon Y., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Fehr T., Ferrari-Lacraz S., Garzoni C., Soccal P.G., Gaudet C., Giostra E., Golshayan D., Hadaya K., Halter J., Heim D., Hess C., Hillinger S., Hirsch H.H., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Laesser B., Lehmann R., Lovis C., Majno P., Manuel O., Marti H.P., Martin P.Y., Meylan P., Mohacsi P., Morel P., Mueller U., Mueller N.J., Mueller-McKenna H., Müller A., Müller T., Müllhaupt B., Nadal D., Pascual M., Passweg J., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Schnyder A., Seiler C., Steiger J., Stirnimann G., Toso C., Van Delden C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1432-2277 (Electronic)
ISSN-L
0934-0874
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
31
Number
11
Pages
1254-1267
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Weight gain after liver transplantation (LTx) facilitates development of new-onset obesity; however, its risk factors and outcomes are poorly understood. We identified the impact of new-onset obesity on cardiovascular events (CVEs) and patient survival, and risk factors for new-onset obesity. Multiple Cox regression models examined risk factors for CVEs, patient survival, and new-onset obesity in 253 adults (mean age 52.2 ± 11.6 years, male gender 63.6%, mean follow up 5.7 ± 2.1 years). Cumulative incidence of post-LTx CVE was 28.1%; that of new-onset obesity was 21.3%. Regardless of CVE at LTx, post-LTx CVEs were predicted by new-onset obesity [Hazard Ratio (HR), 2.95; P = 0.002] and higher age at LTx (HR, 1.05; P < 0.001). In patients without known pre-LTx CVEs (n = 214), risk factors for post-LTx CVEs were new-onset obesity (HR, 2.59; P = 0.014) and higher age (HR, 1.04; P = 0.001). Survival was not associated with new-onset obesity (P = 0.696). Alcoholic liver disease predicted new-onset obesity (HR, 3.37; P = 0.025), female gender was protective (HR, 0.39; P = 0.034). In 114 patients with available genetic data, alcoholic liver disease (HR, 12.82; P = 0.014) and hepatocellular carcinoma (HR, 10.02; P = 0.048) predicted new-onset obesity, and genetics remained borderline significant (HR, 1.07; P = 0.071). Early introduction of post-LTx weight management programs may suggest a potential pathway to reduce CVE risk.
Keywords
alcoholic liver disease, cardiovascular, genetics, obesity, survival
Pubmed
Web of science
Create date
17/07/2018 15:04
Last modification date
20/08/2019 15:56
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