The essential role of radiotherapy in the treatment of Merkel cell carcinoma: a study from the Rare Cancer Network.

Details

Serval ID
serval:BIB_939C5BFD177C
Type
Article: article from journal or magazin.
Collection
Publications
Title
The essential role of radiotherapy in the treatment of Merkel cell carcinoma: a study from the Rare Cancer Network.
Journal
International Journal of Radiation Oncology, Biology, Physics
Author(s)
Ghadjar P., Kaanders J.H., Poortmans P., Zaucha R., Krengli M., Lagrange J.L., Özsoy O., Nguyen T.D., Miralbell R., Baize A., Boujelbene N., Collen T., Scandolaro L., Untereiner M., Goldberg H., Pesce G.A., Anacak Y., Friedrich E.E., Aebersold D.M., Beer K.T.
ISSN
1879-355X (Electronic)
ISSN-L
0360-3016
Publication state
Published
Issued date
2011
Volume
81
Number
4
Pages
e583-e591
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Multicenter Study
Abstract
PURPOSE: To evaluate the role of postoperative radiotherapy (RT) in Merkel cell carcinoma (MCC).
METHODS AND MATERIALS: A retrospective multicenter study was performed in 180 patients with MCC treated between February 1988 and September 2009. Patients who had had surgery alone were compared with patients who received surgery and postoperative RT or radical RT. Local relapse-free survival (LRFS), regional relapse-free survival (RRFS), and distant metastasis-free survival (DMFS) rates were assessed together with disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) rates.
RESULTS: Seventy-nine patients were male and 101 patients were female, and the median age was 73 years old (range, 38-93 years). The majority of patients had localized disease (n = 146), and the remaining patients had regional lymph node metastasis (n = 34). Forty-nine patients underwent surgery for the primary tumor without postoperative RT to the primary site; the other 131 patients received surgery for the primary tumor, followed by postoperative RT (n = 118) or a biopsy of the primary tumor followed by radical RT (n = 13). Median follow-up was 5 years (range, 0.2-16.5 years). Patients in the RT group had improved LRFS (93% vs. 64%; p < 0.001), RRFS (76% vs. 27%; p < 0.001), DMFS (70% vs. 42%; p = 0.01), DFS (59% vs. 4%; p < 0.001), and CSS (65% vs. 49%; p = 0.03) rates compared to patients who underwent surgery for the primary tumor alone; LRFS, RRFS, DMFS, and DFS rates remained significant with multivariable Cox regression analysis. However OS was not significantly improved by postoperative RT (56% vs. 46%; p = 0.2).
CONCLUSIONS: After multivariable analysis, postoperative RT was associated with improved outcome and seems to be an important component in the multimodality treatment of MCC.
Keywords
Adult, Aged, Aged, 80 and over, Carcinoma, Merkel Cell/mortality, Carcinoma, Merkel Cell/radiotherapy, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Recurrence, Local/mortality, Postoperative Care, Rare Diseases/mortality, Rare Diseases/pathology, Regression Analysis, Retrospective Studies, Skin Neoplasms/mortality, Skin Neoplasms/pathology
Pubmed
Web of science
Create date
01/11/2012 19:47
Last modification date
03/03/2018 19:35
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