Immunological and virological responses in HIV-1-infected adults at early stage of established infection treated with highly active antiretroviral therapy.

Details

Serval ID
serval:BIB_93716372A45C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunological and virological responses in HIV-1-infected adults at early stage of established infection treated with highly active antiretroviral therapy.
Journal
AIDS
Author(s)
Bart P.A., Rizzardi G.P., Tambussi G., Chave J.P., Chapuis A.G., Graziosi C., Corpataux J.M., Halkic N., Meuwly J.Y., Munoz M., Meylan P., Spreen W., McDade H., Yerly S., Perrin L., Lazzarin A., Pantaleo G.
ISSN
0269-9370
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
14
Number
13
Pages
1887-1897
Language
english
Notes
Clinical Trial Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep 8
Abstract
OBJECTIVE: To evaluate the immunological and virological responses to highly active antiretroviral therapy (HAART) in blood and lymphoid compartments of HIV-1-infected patients at an early stage of infection. DESIGN: An open-label, observational, non-randomized, prospective trial of outpatients attending the Centre of Clinical Investigation in Infectious Diseases, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland. SUBJECTS: Forty-one antiretroviral-naive HIV-1-infected adults with 400 CD4 T cells/microl or greater and 5000 plasma HIV-1-RNA copies/ml or greater were enrolled, and 32 finished the study. Forty-nine HIV-negative individuals were included as controls. All subjects gave written informed consent. INTERVENTIONS: All patients received abacavir 300 mg by mouth every 12 h and amprenavir 1200 mg by mouth every 12 h for 72 weeks. MAIN OUTCOME MEASURES: The extent of immune reconstitution in blood and lymph nodes after 72 weeks of HAART was evaluated, and compared with immunological measures of 49 HIV-negative subjects. RESULTS: Virus replication was effectively suppressed (-3.5 log10 at week 72). Substantial increments of CD4 T cell count in blood and percentage in lymph nodes were observed over time, and these measures were comparable to HIV-negative subjects by week 24 in blood and by week 48 in lymph nodes. The increase was equally distributed between naive and memory CD4 T cells. Recovery of HIV-specific CD4 responses occurred in 40% of patients. CONCLUSION: The initiation of HAART at an early stage of established HIV infection induces systemic quantitative normalization of CD4 T cells, a partial recovery of HIV-specific CD4 cell responses, and effective and durable suppression of virus replication.
Keywords
Adolescent, Adult, Aged, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-CD8 Ratio, Carbamates, Dideoxynucleosides, Female, HIV Infections, HIV Protease Inhibitors, HIV-1, Humans, Lymph Nodes, Lymphocyte Activation, Male, Middle Aged, Prospective Studies, RNA, Viral, Reverse Transcriptase Inhibitors, Sulfonamides, Viral Load
Pubmed
Web of science
Create date
28/01/2008 10:01
Last modification date
20/08/2019 15:56
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