BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells
Details
Serval ID
serval:BIB_9356B2037066
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells
Journal
Oncogene
ISSN
0950-9232 (Print)
Publication state
Published
Issued date
08/1996
Volume
13
Number
3
Pages
649-53
Notes
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug 1
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug 1
Abstract
The 17q-linked breast and ovarian cancer susceptibility gene (BRCA1) is believed to function as a tumor suppressor gene (Miki et al., 1994). In this report BRCA1 RNA expression has been analysed in adult mouse tissues with detailed attention to its expression in prepuberal and adult testis. Measurements of BRCA1 mRNA levels in highly purified somatic cells of the testis and in staged germ cells showed that high level BRCA1 mRNA expression is limited to the germ cells. Within the germ cell lineage, the high level expression was detected in meiotic cells, specifically pachytene spermatocytes and in post-meiotic round spermatids. This is in contrast to premeiotic germ cells which were found to express little or no BRCA1 mRNA. These observations, considered together with recent data on the expression of BRCA1 in breast epithelium, argues against a function for BRACA1 in early progenitor cells in both tissues and cells attention instead to roles intimately associated with terminal differentiation or with final rounds of cell division.
Keywords
Animals
BRCA1 Protein
Male
Meiosis/physiology
Mice
Mitosis/physiology
Neoplasm Proteins/*biosynthesis
RNA, Messenger/*biosynthesis
Spermatogenesis/*physiology
Spermatozoa/*cytology/*metabolism
Testis/*cytology/*metabolism
Transcription Factors/*biosynthesis
Pubmed
Web of science
Create date
24/01/2008 16:33
Last modification date
20/08/2019 15:56