Autism and psychosis: Clinical implications for depression and suicide.

Details

Serval ID
serval:BIB_9335A04DCA02
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Autism and psychosis: Clinical implications for depression and suicide.
Journal
Schizophrenia research
Author(s)
Upthegrove R., Abu-Akel A., Chisholm K., Lin A., Zahid S., Pelton M., Apperly I., Hansen P.C., Wood S.J.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
195
Pages
80-85
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
There is increasing recognition of the co-occurrence of autism and schizophrenia spectrum disorders. However, the clinical significance of this on outcomes such as depression and suicidal thinking has not been explored. This study examines the association of autism spectrum traits, depressive symptoms and suicidal behaviour in individuals with psychotic experiences. In two cross sectional studies, individuals from a non-help seeking university student sample and patients with first episode psychosis (FEP) service completed standardized measures of autism spectrum traits, psychotic experiences, depressive symptoms and suicidal thinking. In healthy non-help seeking students, increased autism traits and increased subclinical psychotic experiences were significantly associated with depressive symptoms; a significant interaction effect suggests their combined presence has a greater impact on depression. In FEP, high autism traits and positive symptoms were associated with increased depression, hopelessness and suicidality, however there was no significant interaction effect. In FEP a multiple mediation model revealed that the relationship between autism traits and risk for suicidality was mediated through hopelessness. Young people with subclinical psychotic experiences and all patients with FEP should be screened for autism spectrum traits, which may have significant impact on clinical outcomes. Tailored interventions for patients with high levels of autistic spectrum co-morbidities in FEP should be a priority for future research.
Keywords
Adolescent, Adult, Autistic Disorder/complications, Autistic Disorder/psychology, Depression/etiology, Depression/psychology, Female, Help-Seeking Behavior, Humans, Male, Psychotic Disorders/complications, Psychotic Disorders/psychology, Suicide/psychology, Young Adult, Autism, Autism spectrum disorders, Depression, Psychosis, Schizophrenia, Suicide
Pubmed
Web of science
Create date
08/09/2017 22:02
Last modification date
20/08/2019 14:56
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