Subretinal migration of PFCL bubbles may occur dur- ing vitreoretinal surgery. Removal of subretinal PFCL is, however, necessary to prevent persistent focal retinal detachments and direct toxic effects on photoreceptor cells. History and Signs A 69-year-old woman presented with a total retinal detachment due to multiple retinal holes and tears in the peripheral nasal retina of her left eye. During the surgical intervention comprising a vitrectomy and sili- cone oil tamponade, PFCL moved into the subretinal space through a macular hole inadvertently caused by the PFCL’s fluid jet. Therapy and Outcome After a repeated postoperative steamroller manoeuvre and positioning on the right side, the PFCL droplets could be dis- placed into the posterior chamber through the retinal holes of the peripheral nasal retina. Intraocular silicone oil removal combined with cataract surgery was performed several months later. At the last follow-up 19 months later visual acuity was 0.8 and the retina was re-attached. Conclusions Removal of subretinal PFCL by posi- tioning seems to be safe and effective and is an alternative to direct aspiration of PFCL through a retinotomy, which invariably causes damage to the retina.