Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: results of a prospective phase II trial.

Details

Serval ID
serval:BIB_9323C065A8E4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: results of a prospective phase II trial.
Journal
Annals of surgery
Author(s)
Heinrich S., Schäfer M., Weber A., Hany T.F., Bhure U., Pestalozzi B.C., Clavien P.A.
ISSN
1528-1140 (Electronic)
ISSN-L
0003-4932
Publication state
Published
Issued date
12/2008
Peer-reviewed
Oui
Volume
248
Number
6
Pages
1014-1022
Language
english
Notes
Publication types: Clinical Trial, Phase II ; Journal Article
Publication Status: ppublish
Abstract
To evaluate the morbidity of pancreaticoduodenectomy after neoadjuvant chemotherapy for resectable pancreatic cancer and to assess its histologic and metabolic response.
Adjuvant chemotherapy improves the outcome of pancreatic cancer, but 25% of patients remain unfit after surgery. Neoadjuvant chemotherapy can be offered to all patients in a multimodality approach, but its efficacy and surgical morbidity are unknown.
Patients with resectable, cytologically proven adenocarcinoma of the pancreatic head received 4 bi-weekly cycles of gemcitabine (1000 mg/m(2)) and cisplatin (50 mg/m(2)) in this prospective phase II trial. Staging and restaging included chest x-ray, abdominal computed tomography (CT), positron emission tomography (PET)/CT, endoscopic ultrasound, and laparoscopy. Fluorodeoxyglucose uptake was quantified by the standard-uptake value (SUV) on baseline and restaging PET/CT. Immunohistochemistry for GLUT-1 and Ki-67 was performed. The histologic response, cytopathic effects, and surgical complications were graded by respective scores.
Twenty-four of 28 patients had resection for histologically confirmed adenocarcinoma. The surgical morbidity was low without perioperative death and one pancreatic fistula. Histologic response was documented in 54% and cytopathic effects in 83% of the patients. A significant SUV decrease occurred during chemotherapy (P = 0.031), which correlated with the baseline SUV (P = 0.001), Ki-67 expression (P = 0.016), and histologic response (P = 0.01). Neither the metabolic nor the histologic response was predictive of the median disease-free (9.2 months) or overall survival (26.5 months).
Neoadjuvant chemotherapy induced a significant metabolic and histologic response, which was best predicted by PET. Most importantly, surgery after neoadjuvant chemotherapy for pancreatic cancer was safe.
Keywords
Adenocarcinoma/blood, Adenocarcinoma/drug therapy, Adenocarcinoma/mortality, Adenocarcinoma/surgery, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, CA-19-9 Antigen/blood, Chemotherapy, Adjuvant, Cisplatin/administration & dosage, Deoxycytidine/administration & dosage, Deoxycytidine/analogs & derivatives, Disease-Free Survival, Humans, Morbidity, Neoadjuvant Therapy, Pancreatic Neoplasms/blood, Pancreatic Neoplasms/drug therapy, Pancreatic Neoplasms/mortality, Pancreatic Neoplasms/surgery, Pancreaticoduodenectomy, Positron-Emission Tomography, Prospective Studies
Pubmed
Web of science
Create date
11/12/2018 15:23
Last modification date
20/08/2019 14:56
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