A fly view on the roles and mechanisms of the m<sup>6</sup>A mRNA modification and its players.

Details

Serval ID
serval:BIB_931A0BE4FA8B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
A fly view on the roles and mechanisms of the m<sup>6</sup>A mRNA modification and its players.
Journal
RNA biology
Author(s)
Lence T., Soller M., Roignant J.Y.
ISSN
1555-8584 (Electronic)
ISSN-L
1547-6286
Publication state
Published
Issued date
02/09/2017
Peer-reviewed
Oui
Volume
14
Number
9
Pages
1232-1240
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N <sup>6</sup> -methyladenosine (m <sup>6</sup> A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m <sup>6</sup> A in mRNA is dynamically regulated. A conserved methyltransferase complex catalyzes the deposition of the methyl group on adenosine, which can be removed by specific classes of demethylases. Furthermore, YTH-domain containing proteins can recognize this modification to mediate m <sup>6</sup> A-dependent activities. Here we review the functions and mechanisms of the main m <sup>6</sup> A players with a particular focus on Drosophila melanogaster.
Keywords
Adenosine/analogs & derivatives, Adenosine Triphosphatases/chemistry, Adenosine Triphosphatases/metabolism, Animals, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Gene Expression Regulation, Methylation, RNA Splicing, RNA, Messenger/genetics, RNA, Messenger/metabolism, Drosophila, RNA modifications, Sex lethal, m6A, neurogenesis, splicing
Pubmed
Web of science
Open Access
Yes
Create date
28/10/2019 12:52
Last modification date
29/10/2019 6:26
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