Validation of a Prognostic Staging for Metastatic Uveal Melanoma: A Collaborative Study of the European Ophthalmic Oncology Group.

Details

Serval ID
serval:BIB_9314C1F3862F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Validation of a Prognostic Staging for Metastatic Uveal Melanoma: A Collaborative Study of the European Ophthalmic Oncology Group.
Journal
American journal of ophthalmology
Author(s)
Kivelä T.T., Piperno-Neumann S., Desjardins L., Schmittel A., Bechrakis N., Midena E., Leyvraz S., Zografos L., Grange J.D., Ract-Madoux G., Marshall E., Damato B., Eskelin S.
ISSN
1879-1891 (Electronic)
ISSN-L
0002-9394
Publication state
Published
Issued date
08/2016
Peer-reviewed
Oui
Volume
168
Pages
217-226
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Validation Studies
Publication Status: ppublish
Abstract
To validate a staging system for metastatic uveal melanoma that will facilitate planning, reporting, and interpreting the results of clinical trials.
Reliability and validity study.
The performance index, the largest diameter of the largest metastasis and alkaline phosphatase level at the time of diagnosis of metastases, and overall survival of 249 patients from 7 ocular oncology centers who died of dissemination were analyzed. Predicted median survival time calculated according to the Helsinki University Hospital Working Formulation was used to assign patients to stages IVa, IVb, and IVc, which correspond to predicted survival times of ≥12, <12-6, and <6 months, respectively. The predictions were compared against observed survival.
The 3 variables used to assign stage were independent predictors of survival in the validation dataset. Of the 249 patients, 110 (44%), 109 (44%), and 30 (12%) were classified to Working Formulation stages IVa, IVb, and IVc, respectively. Corresponding median observed survival times were 18.6, 10.7, and 4.6 months and worsened by increasing stage (P < .001). Of 201 patients managed without surgical resection of metastases, 83 (41%), 89 (44%), and 29 (15%) were classified to stages IVa, IVb, and IVc, respectively, and their median observed survival times were 17.2, 10.0, and 4.6 months (P < .001). Survival of 47 patients who underwent resection did not differ by working formulation stage (P = .69).
This multicenter study confirms that the Working Formulation is a reliable and valid, repeatable system for dividing metastatic uveal melanoma into distinct prognostic subgroups, especially for stage-specific reporting of survival in prospective clinical trials.

Keywords
Adult, Aged, Alkaline Phosphatase/blood, Female, Humans, Male, Melanoma/enzymology, Melanoma/pathology, Melanoma/secondary, Middle Aged, Neoplasm Staging/methods, Neoplasm Staging/standards, Predictive Value of Tests, Prognosis, Regression Analysis, Retrospective Studies, Severity of Illness Index, Survival Analysis, Uveal Neoplasms/enzymology, Uveal Neoplasms/pathology, Uveal Neoplasms/secondary
Pubmed
Create date
18/06/2016 16:13
Last modification date
20/08/2019 14:55
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