Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
Details
Serval ID
serval:BIB_930B74C0D02E
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
Journal
Dermatology
ISSN
1018-8665
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
195
Number
1
Pages
93-5
Notes
Case Reports
Journal Article
Journal Article
Abstract
We report the case of a 75-year-old woman with a 15-year history of inappetance resulting in weight loss of approximately 40 kg. On physical examination, the skin of the lower extremities was markedly hyperpigmented with a brown-greyish hue. In addition, the skin of the legs was infiltrated, erythematous, riddled with erosions and necrotic ulcers. Clinical and laboratory evaluation revealed sicca syndrome, a pronounced polyclonal hypergammaglobulinemia (60 g/l), high levels of antinuclear, anti-SSA and anti-SSB antibodies. Histological examination of involved skin demonstrated a leukocytoclastic vasculitis.
Keywords
Adenosine Triphosphatases/immunology
Aged
Anorexia/diagnosis/*pathology
Autoantibodies/analysis
Autoantigens/analysis
Chronic Disease
Erythema/pathology
Female
Humans
Hypergammaglobulinemia/pathology
Hyperpigmentation/pathology
Leg Ulcer/*pathology
Necrosis
*RNA, Small Cytoplasmic
Ribonucleoproteins/analysis
Sjogren's Syndrome/diagnosis/*pathology
Vasculitis, Hypersensitivity/pathology
Weight Loss
Pubmed
Web of science
Create date
15/02/2008 14:07
Last modification date
20/08/2019 15:55