Functional neuroimaging strategy in temporal lobe epilepsy: a comparative study of 18FDG-PET and 99mTc-HMPAO-SPECT

Details

Serval ID
serval:BIB_93030856C3CD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Functional neuroimaging strategy in temporal lobe epilepsy: a comparative study of 18FDG-PET and 99mTc-HMPAO-SPECT
Journal
Ann Neurol
Author(s)
Ryvlin P., Philippon B., Cinotti L., Froment J. C., Le Bars D., Mauguiere F.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
06/1992
Volume
31
Number
6
Pages
650-6
Language
english
Notes
Ryvlin, P
Philippon, B
Cinotti, L
Froment, J C
Le Bars, D
Mauguiere, F
eng
Research Support, Non-U.S. Gov't
Ann Neurol. 1992 Jun;31(6):650-6. doi: 10.1002/ana.410310613.
Abstract
We performed 99mTc-hexamethylpropyleneamineoxime-single-photon emission computed tomography (SPECT) and 18F-fluorodeoxyglucose-positron emission tomography (PET) in 20 epileptic patients with well-lateralized temporal electroencephalographic focus, normal computed tomographic scan, and brain magnetic resonance imaging (MRI) either normal (n = 10) or showing nonspecific changes in the epileptogenic temporal lobe (n = 10). In patients with a normal MRI, PET exhibited focal hypometabolism in 80%, whereas SPECT showed corresponding hypoperfusion in only 20%. In patients with an abnormal MRI, PET and SPECT yielded 100% and 90% sensitivity, respectively. The metabolic and regional cerebral blood flow disturbances were topographically concordant with electroencephalographic and MRI findings in all these patients. Only patients with a large and pronounced hypometabolism on PET images exhibited hypoperfusion on SPECT. Spatial resolution appeared to be the critical factor responsible for the higher sensitivity of PET. However, this superiority of PET did not prove clinically useful in patients whose SPECT was abnormal, particularly when brain MRI showed nonspecific changes in the epileptogenic temporal lobe.
Keywords
Adolescent, Adult, Deoxyglucose/*analogs & derivatives, Epilepsy, Temporal Lobe/*diagnostic imaging, Female, *Fluorine Radioisotopes, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, *Organotechnetium Compounds, *Oximes, Seizures, Febrile/diagnostic imaging, Technetium Tc 99m Exametazime, *Tomography, Emission-Computed, *Tomography, Emission-Computed, Single-Photon
Pubmed
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29/11/2018 12:37
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20/08/2019 14:55
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