Mycoplasma hominis in mid-trimester amniotic fluid: relation to pregnancy outcome.
Details
Serval ID
serval:BIB_930156C987BC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mycoplasma hominis in mid-trimester amniotic fluid: relation to pregnancy outcome.
Journal
Journal of perinatal medicine
ISSN
0300-5577 (Print)
ISSN-L
0300-5577
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
32
Number
4
Pages
323-326
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
The relationship between detection of Mycoplasma hominis in mid-trimester amniotic fluid and subsequent pregnancy outcome was investigated.
Amniotic fluids from 456 women of European background who underwent a transabdominal amniocentesis at weeks 15-17 of pregnancy were tested for M. hominis by polymerase chain reaction (PCR). The amplicons were hybridized to an internal probe and detected by ELISA. Pregnancy outcomes and clinical data were subsequently obtained.
M. hominis were identified in 29 (6.4%) of the amniotic fluids. The rate of preterm labor in women positive for M. hominis (14.3%) was higher than in the negative women (3.3%) (p=0.01). Similarly, a spontaneous preterm birth with intact membranes occurred in 10.7% of the M. hominis-positive women as opposed to only 1.9% of the negative women (p = 0.02). The presence of this mycoplasma was not correlated with fetal chromosomal aberrations, intrauterine growth restriction or preeclampsia.
Detection of M. hominis in second-trimester amniotic fluids can identify women at increased risk for subsequent preterm labor and delivery.
Amniotic fluids from 456 women of European background who underwent a transabdominal amniocentesis at weeks 15-17 of pregnancy were tested for M. hominis by polymerase chain reaction (PCR). The amplicons were hybridized to an internal probe and detected by ELISA. Pregnancy outcomes and clinical data were subsequently obtained.
M. hominis were identified in 29 (6.4%) of the amniotic fluids. The rate of preterm labor in women positive for M. hominis (14.3%) was higher than in the negative women (3.3%) (p=0.01). Similarly, a spontaneous preterm birth with intact membranes occurred in 10.7% of the M. hominis-positive women as opposed to only 1.9% of the negative women (p = 0.02). The presence of this mycoplasma was not correlated with fetal chromosomal aberrations, intrauterine growth restriction or preeclampsia.
Detection of M. hominis in second-trimester amniotic fluids can identify women at increased risk for subsequent preterm labor and delivery.
Keywords
Adult, Amniocentesis, Amniotic Fluid/microbiology, DNA, Bacterial/analysis, Female, Humans, Mycoplasma Infections/complications, Mycoplasma Infections/diagnosis, Mycoplasma Infections/epidemiology, Mycoplasma Infections/microbiology, Mycoplasma hominis/genetics, Mycoplasma hominis/isolation & purification, Obstetric Labor, Premature/etiology, Polymerase Chain Reaction, Pregnancy, Pregnancy Complications, Infectious/diagnosis, Pregnancy Complications, Infectious/epidemiology, Pregnancy Complications, Infectious/microbiology, Pregnancy Outcome, Pregnancy Trimester, Second, Prenatal Diagnosis, Switzerland/epidemiology
Pubmed
Web of science
Create date
25/01/2008 11:12
Last modification date
20/08/2019 14:55
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