Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity.

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State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_929CE1B44769
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity.
Journal
iScience
Author(s)
Burtscher J., Cappellano G., Omori A., Koshiba T., Millet G.P.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
23/10/2020
Peer-reviewed
Oui
Volume
23
Number
10
Pages
101631
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The pathophysiology, immune reaction, and differential vulnerability of different population groups and viral host immune system evasion strategies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategies of coronaviruses and other viruses to usurp mitochondria-associated mechanisms involved in the host innate immune response and put them in context with the current knowledge on SARS-CoV-2. We argue that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2. Mitochondrial health thus may determine differential vulnerabilities to SARS-CoV-2 infection rendering markers of mitochondrial functions promising potential biomarkers for SARS-CoV-2 infection risk and severity of outcome. Current knowledge gaps on our understanding of mitochondrial involvement in SARS-CoV-2 infection, lifestyle, and pharmacological strategies to improve mitochondrial integrity and potential reciprocal interactions with chronic and age-related diseases, e.g., Parkinson disease, are pointed out.
Keywords
Cell Biology, Immunology, Virology
Pubmed
Web of science
Open Access
Yes
Create date
09/10/2020 14:12
Last modification date
22/02/2021 10:53
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