Microcrystals as DAMPs and their role in joint inflammation.

Details

Ressource 1Download: serval:BIB_925220FB32EE.P001 (222.59 [Ko])
State: Public
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_925220FB32EE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Microcrystals as DAMPs and their role in joint inflammation.
Journal
Rheumatology (oxford, England)
Author(s)
Busso N., So A.
ISSN
1462-0332 (Electronic)
ISSN-L
1462-0324
Publication state
Published
Issued date
2012
Volume
51
Number
7
Pages
1154-1160
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
Microcrystals associated with joint diseases, namely monosodium urate, calcium pyrophosphate and basic calcium phosphate, can be considered as 'danger signals' to the innate immune system and provoke inflammation through inflammasome-dependent as well as inflammasome-independent pathways. Direct crystal membrane interactions can also lead to cell activation. The result is the generation of IL-1β and other pro-inflammatory cytokines. The primacy of IL-1β in the case of gouty inflammation has been demonstrated by the efficacy of IL-1 inhibitors in clinical studies. These findings may be relevant to other diseases where crystal formation is found, such as OA and atherosclerosis.
Keywords
Arthritis/immunology, Arthritis/metabolism, Humans, Immunity, Innate, Inflammasomes/immunology, Inflammasomes/metabolism, Inflammation Mediators/immunology, Inflammation Mediators/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2012 15:52
Last modification date
25/09/2019 7:10
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