Signatures of life course socioeconomic conditions in brain anatomy.

Details

Serval ID
serval:BIB_923026258FA8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Signatures of life course socioeconomic conditions in brain anatomy.
Journal
Human brain mapping
Author(s)
Loued-Khenissi L., Trofimova O., Vollenweider P., Marques-Vidal P., Preisig M., Lutti A., Kliegel M., Sandi C., Kherif F., Stringhini S., Draganski B.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Publication state
Published
Issued date
01/06/2022
Peer-reviewed
Oui
Volume
43
Number
8
Pages
2582-2606
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the brain anatomy signatures of SES in a large-scale population cohort aged 45-85 years. We assess both gray matter morphometry and tissue properties indicative of myelin content. Higher life course SES is associated with increased volume in several brain regions, including postcentral and temporal gyri, cuneus, and cerebellum. We observe more widespread volume differences and higher myelin content in the sensorimotor network but lower myelin content in the temporal lobe associated with childhood SES. Crucially, childhood SES differences persisted in adult brains even after controlling for adult SES, highlighting the unique contribution of early-life conditions to brain anatomy, independent of later changes in SES. These findings inform on the biological underpinnings of social inequality, particularly as they pertain to early-life conditions.
Keywords
Adult, Brain/anatomy & histology, Brain/diagnostic imaging, Child, Gray Matter/diagnostic imaging, Humans, Life Change Events, Social Class, Socioeconomic Factors, multiparametric maps, quantitative MRI, socioeconomic status
Pubmed
Web of science
Open Access
Yes
Create date
27/02/2022 12:24
Last modification date
17/05/2022 6:36
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