From current immunosuppressive strategies to clinical tolerance of allografts.

Details

Serval ID
serval:BIB_922E48F4882B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
From current immunosuppressive strategies to clinical tolerance of allografts.
Journal
Transplant International
Author(s)
Golshayan D., Buhler L., Lechler R.I., Pascual M.
ISSN
0934-0874
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
20
Number
1
Pages
12-24
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
In order to prevent allograft rejection, most current immunosuppressive drugs nonspecifically target T-cell activation, clonal expansion or differentiation into effector cells. Experimental models have shown that it is possible to exploit the central and peripheral mechanisms that normally maintain immune homeostasis and tolerance to self-antigens, in order to induce tolerance to alloantigens. Central tolerance results from intrathymic deletion of T cells with high avidity for thymically expressed antigens. Peripheral tolerance to nonself-molecules can be achieved by various mechanisms including deletion of activated/effector T cells, anergy induction and active regulation of effector T cells. In this article, we briefly discuss the pathways of allorecognition and their relevance to current immunosuppressive strategies and to the induction of transplantation tolerance (through haematopoietic mixed chimerism, depleting protocols, costimulatory blockade and regulatory T cells). We then review the prospect of clinical applicability of these protocols in solid organ transplantation.
Keywords
Humans, Immunosuppression, Immunosuppressive Agents, Lymphocyte Activation, Models, Immunological, T-Lymphocytes, Transplantation Immunology, Transplantation, Homologous
Pubmed
Web of science
Create date
29/01/2008 14:53
Last modification date
03/03/2018 19:31
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