Ageing with HIV: medication use and risk for potential drug-drug interactions.

Details

Ressource 1Download: serval:BIB_91EDE0960CA0.P001 (166.89 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_91EDE0960CA0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ageing with HIV: medication use and risk for potential drug-drug interactions.
Journal
Journal of Antimicrobial Chemotherapy
Author(s)
Marzolini C., Back D., Weber R., Furrer H., Cavassini M., Calmy A., Vernazza P., Bernasconi E., Khoo S., Battegay M., Elzi L.
Working group(s)
Swiss HIV Cohort Study Members
Contributor(s)
Battegay M., Bernasconi E., Böni J., Bucher HC., Bürgisser P., Calmy A., Cattacin S., Cavassini M., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer H., Fux C., Gorgievski M., Günthard H., Hirsch HH., Hirschel B., Hösli I., Kahlert Ch., Kaiser L., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Martinez B., Müller N., Nadal D., Opravil M., Paccaud F., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schüpbach J., Speck R., Taffé P., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1460-2091 (Electronic)
ISSN-L
0305-7453
Publication state
Published
Issued date
2011
Volume
66
Number
9
Pages
2107-2111
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVES: To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥ 50 years or <50 years.
METHODS: All ART-treated participants were prospectively included once during a follow-up visit of the Swiss HIV Cohort Study. Information on any current medication was obtained by participant self-report and medical prescription history. The complete treatment was subsequently screened for PDDIs using a customized version of the Liverpool drug interaction database.
RESULTS: Drug prescriptions were analysed for 1497 HIV-infected individuals: 477 age ≥ 50 and 1020 age <50. Older patients were more likely to receive one or more co-medications compared with younger patients (82% versus 61%; P < 0.001) and thus had more frequent PDDIs (51% versus 35%; P < 0.001). Furthermore, older patients tended to use a higher number of co-medications and certain therapeutic drug classes more often, such as cardiovascular drugs (53% versus 19%; P < 0.001), gastrointestinal medications (10% versus 6%; P = 0.004) and hormonal agents (6% versus 3%; P = 0.04). PDDIs with ART occurred mainly with cardiovascular drugs (27%), CNS agents (22%) and methadone (6%) in older patients and with CNS agents (27%), methadone (15%) and cardiovascular drugs (11%) in younger patients. The response to ART did not differ between the two groups.
CONCLUSIONS: The risk for PDDIs with ART increased in older patients who take more drugs than their younger HIV-infected counterparts. However, medication use in older and younger patients did not differ in terms of effect on antiretroviral tolerability and response.
Keywords
Adult, Aged, Aging/physiology, Anti-HIV Agents/adverse effects, Anti-HIV Agents/therapeutic use, Antiretroviral Therapy, Highly Active/adverse effects, Cardiovascular Agents/adverse effects, Cardiovascular Agents/therapeutic use, Central Nervous System Agents/adverse effects, Central Nervous System Agents/therapeutic use, Cohort Studies, Drug Interactions, Drug Prescriptions/statistics & numerical data, Female, Follow-Up Studies, Gastrointestinal Agents/adverse effects, Gastrointestinal Agents/therapeutic use, HIV Infections/complications, HIV Infections/drug therapy, Hormones/adverse effects, Hormones/therapeutic use, Humans, Male, Methadone/adverse effects, Methadone/therapeutic use, Middle Aged, Narcotics/adverse effects, Narcotics/therapeutic use, Socioeconomic Factors, Substance Abuse, Intravenous/complications, Substance-Related Disorders/complications, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2011 13:57
Last modification date
01/10/2019 7:18
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