Epidemiology and prognostic factors of critically ill patients treated with hemodiafiltration

Details

Serval ID
serval:BIB_91E9305ED972
Type
Article: article from journal or magazin.
Collection
Publications
Title
Epidemiology and prognostic factors of critically ill patients treated with hemodiafiltration
Journal
J Crit Care
Author(s)
Soubrier S., Leroy O., Devos P., Nseir S., Georges H., d'Escrivan T., Guery B.
ISSN
0883-9441 (Print)
ISSN-L
0883-9441
Publication state
Published
Issued date
03/2006
Volume
21
Number
1
Pages
66-72
Language
english
Notes
Soubrier, Stephane
Leroy, Olivier
Devos, Patrick
Nseir, Saad
Georges, Hugues
d'Escrivan, Thibaud
Guery, Benoit
eng
J Crit Care. 2006 Mar;21(1):66-72. doi: 10.1016/j.jcrc.2005.08.004.
Abstract
PURPOSE: The objective of this study is to study the epidemiology, outcome, and prognostic factors of critically ill patients treated with continuous venovenous hemodiafiltration (CVVHDF). MATERIALS AND METHODS: Observational cohort was done in a French 16-bed intensive care unit (ICU) from a university-affiliated urban hospital. All patients requiring, in the opinion of the treating physician, the initiation of CVVHDF were included in the study. RESULTS: One hundred ninety-seven patients with acute renal failure (ARF) treated with CVVHDF were studied. The incidence of ARF treated with CVVHDF was 5.9% in the ICU with a mortality rate of 71.6%. A multivariate analysis identified 3 independent factors associated with fatal outcome: mechanical ventilation, sepsis, and septic shock requiring vasoactive drug. In contrast, 2 independent factors predicted a favorable outcome: nonoliguric ARF and serum creatinine concentration higher than 34 mg/L at CVVHDF initiation. A flowchart determined by the chi2 Automatic Interaction and Detection statistical method allowed for the identification of patients' subgroups with different mortality rates ranging from 25% to 100%. CONCLUSIONS: In our series, ARF treated with CVVHDF was associated with a high overall ICU mortality rate (71.6%). However, our prognostic flowchart identified patients with low mortality rates for which renal replacement therapy must be initiated with no discussion as soon as required.
Keywords
Acute Kidney Injury/mortality/*therapy, Aged, Chi-Square Distribution, *Critical Illness, Female, France/epidemiology, *Hemodiafiltration, Humans, Incidence, Male, Multivariate Analysis, Outcome Assessment, Health Care, Prognosis, Retrospective Studies
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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