Folate intake and risk of oral and pharyngeal cancer

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_91739103BA21
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Folate intake and risk of oral and pharyngeal cancer
Journal
Annals of Oncology
Author(s)
Pelucchi  Claudio, Talamini  Renato, Negri  Eva, Conti  E., Franceschi  Silvia, La Vecchia  Carlo
ISSN
0923-7534
Publication state
Published
Issued date
2003
Volume
14
Number
11
Pages
1677-1681
Notes
Réf. IUMSP: R 03/106
SAPHIRID:44959
Abstract
[Abstract] BACKGROUND: Diet has been recognised as having a role in the aetiology of oral and pharyngeal cancer, and dietary factors may account for 10-15% of cases in Europe. Folate deficiency has been linked to risk of several cancers, but has not been studied adequately with respect to oral cancer. PATIENTS AND METHODS: This case-control study, conducted in Italy and French-speaking Switzerland, included 749 patients with incident cancer of the oral cavity and pharynx, and 1772 hospital controls with acute, non-neoplastic conditions. The interviews used a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multiple logistic regression. RESULTS: The ORs were 0.68 (95% CI 0.52-0.88) for the intermediate tertile and 0.53 (95% CI 0.40-0.69) for the highest tertile of dietary folate intake, compared with the lowest tertile. No heterogeneity was found in strata of gender, age, methionine intake or alcohol consumption. The combined OR for low-folate and high-alcohol intake versus high-folate and low-alcohol intake was 22.3 (95% CI 13.1-38). CONCLUSIONS: Our study supports a protective role of folate against oral and pharyngeal carcinogenesis. Compared with low folate intake, a consistent reduction in risk was already observed from intermediate levels of intake, suggesting that cancer risk may be related to relative folate deficiency. [Authors]
Keywords
Folic Acid , Folic Acid Deficiency , Food Habits , Mouth Neoplasms , Pharyngeal Neoplasms
Pubmed
Web of science
Open Access
Yes
Create date
06/03/2008 16:30
Last modification date
25/09/2019 7:10
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