Activity measurements of 18F and 90Y with commercial radionuclide calibrators for nuclear medicine in Switzerland.

Details

Serval ID
serval:BIB_914332C6DCD8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Activity measurements of 18F and 90Y with commercial radionuclide calibrators for nuclear medicine in Switzerland.
Journal
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use In Agriculture, Industry and Medicine
Author(s)
Caffari Y., Spring P., Bailat C., Nedjadi Y., Bochud F.
ISSN
1872-9800[electronic], 0969-8043[linking]
Publication state
Published
Issued date
2010
Volume
68
Number
7-8
Pages
1388-1391
Language
english
Abstract
The activity of radiopharmaceuticals in nuclear medicine is measured before patient injection with radionuclide calibrators. In Switzerland, the general requirements for quality controls are defined in a federal ordinance and a directive of the Federal Office of Metrology (METAS) which require each instrument to be verified. A set of three gamma sources (Co-57, Cs-137 and Co-60) is used to verify the response of radionuclide calibrators in the gamma energy range of their use. A beta source, a mixture of (90)Sr and (90)Y in secular equilibrium, is used as well. Manufacturers are responsible for the calibration factors. The main goal of the study was to monitor the validity of the calibration factors by using two sources: a (90)Sr/(90)Y source and a (18)F source. The three types of commercial radionuclide calibrators tested do not have a calibration factor for the mixture but only for (90)Y. Activity measurements of a (90)Sr/(90)Y source with the (90)Y calibration factor are performed in order to correct for the extra-contribution of (90)Sr. The value of the correction factor was found to be 1.113 whereas Monte Carlo simulations of the radionuclide calibrators estimate the correction factor to be 1.117. Measurements with (18)F sources in a specific geometry are also performed. Since this radionuclide is widely used in Swiss hospitals equipped with PET and PET-CT, the metrology of the (18)F is very important. The (18)F response normalized to the (137)Cs response shows that the difference with a reference value does not exceed 3% for the three types of radionuclide calibrators.
Keywords
Calibration, Equipment Design, Fluorodeoxyglucose F18/analysis, Fluorodeoxyglucose F18/standards, Nuclear Medicine/standards, Radiation Dosage, Radiopharmaceuticals/standards, Switzerland, Yttrium Radioisotopes/analysis, Yttrium Radioisotopes/standards
Pubmed
Web of science
Create date
01/10/2010 19:10
Last modification date
03/03/2018 19:28
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