Sleep, Hansen's disease and the immune system--a not so harmonic triad.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_9123ADDE9D77
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sleep, Hansen's disease and the immune system--a not so harmonic triad.
Journal
Medical hypotheses
Author(s)
Albuquerque R.G., Okazaki K.M., Hirotsu C., Tomimori J., Tufik S., Andersen M.L.
ISSN
1532-2777 (Electronic)
ISSN-L
0306-9877
Publication state
Published
Issued date
05/2015
Peer-reviewed
Oui
Volume
84
Number
5
Pages
456-459
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hansen's disease is one of the oldest skin diseases in the world characterized by a spectrum of clinical manifestations that are associated with stigmatization and poor quality of life. It is also considered a model disease for investigating the human immune system because of its association with immune reactions, which are thought to be a reflection of the host's immunological response, promoting intense cellular activity or humoral secretion. This relationship between the cellular and microbial components of skin and their regulation by local immune responses may be modulated by a currently neglected behavior: sleep. Recent studies have demonstrated that sleep deprivation may aggravate the progression of chronic dermatological diseases, which in turn can lead to a non-restorative sleep pattern. Indeed, sleep is essential for immune and skin integrity. Thus, we propose here a hypothesis linking Hansen's disease, sleep and immunity in a bidirectional relationship. Hansen's disease patients may demonstrate a worse sleep quality than the general population through the modulation of immunological environment; and sleep restriction, a hallmark of modern society, being a possible predictor of the disease progression.
Keywords
Humans, Leprosy/immunology, Models, Biological, Skin/immunology, Skin/physiopathology, Sleep/immunology
Pubmed
Web of science
Create date
17/12/2019 17:06
Last modification date
04/08/2020 6:23
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