Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.

Details

Ressource 1Download: Levi_Kawakita_fiber_INHANCE.pdf (1146.12 [Ko])
State: Serval
Version: Author's accepted manuscript
Serval ID
serval:BIB_90D9A996AF06
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
Journal
International journal of cancer
Author(s)
Kawakita D., Lee Y.A., Turati F., Parpinel M., Decarli A., Serraino D., Matsuo K., Olshan A.F., Zevallos J.P., Winn D.M., Moysich K., Zhang Z.F., Morgenstern H., Levi F., Kelsey K., McClean M., Bosetti C., Garavello W., Schantz S., Yu G.P., Boffetta P., Chuang S.C., Hashibe M., Ferraroni M., La Vecchia C., Edefonti V.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Publication state
Published
Issued date
01/11/2017
Peer-reviewed
Oui
Volume
141
Number
9
Pages
1811-1821
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual-level pooled data from ten case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend <0.001) and with laryngeal cancer (OR = 0.66, 95% CI: 0.54-0.82, p for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large-scale pooled analysis suggest that, although in the presence of between-study heterogeneity, a greater intake of fiber may lower HNC risk.

Keywords
INHANCE, dietary fiber intake, head and neck cancer, laryngeal cancer, oral cavity and pharyngeal cancer
Pubmed
Web of science
Create date
27/07/2017 10:48
Last modification date
03/03/2018 19:26
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