Evidence for limbic system activation during CO2-stimulated breathing in man.

Details

Serval ID
serval:BIB_90C0093EC6F1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Evidence for limbic system activation during CO2-stimulated breathing in man.
Journal
Journal of Physiology
Author(s)
Corfield D.R., Fink G.R., Ramsay S.C., Murphy K., Harty H.R., Watson J.D., Adams L., Frackowiak R.S., Guz A.
ISSN
0022-3751 (Print)
ISSN-L
0022-3751
Publication state
Published
Issued date
1995
Volume
488 ( Pt 1)
Pages
77-84
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
1. The role of supra-brainstem structures in the ventilatory response to inhaled CO2 is unknown. The present study uses positron emission tomography (PET), with infusion of H2(15)O, to measure changes in relative regional cerebral blood flow (rCBF) in order to identify sites of increased neuronal activation during CO2-stimulated breathing (CO2-SB) in awake man. 2. Five male volunteers were scanned during CO2-SB (mean +/- S.E.M.; end-tidal PCO2, 50.3 +/- 1.7 mmHg; respiratory frequency, 16.4 +/- 2.7 min-1; tidal volume, 1.8 +/- 0.2 l). As control, scans were performed during 'passive' isocapnic (elevated fraction of inspired CO2) positive pressure ventilation (end-tidal PCO2, 38.4 +/- 1.0 mmHg; respiratory frequency, 15.5 +/- 2.2 min-1; tidal volume, 1.6 +/- 0.2 l). With CO2-SB, all subjects reported dyspnoea. 3. The anatomical locations of the increases in relative rCBF (CO2-SB versus control) were obtained using magnetic resonance imaging. 4. Group analysis identified neuronal activation within the upper brainstem, midbrain and hypothalamus, thalamus, hippocampus and parahippocampus, fusiform gyrus, cingulate area, insula, frontal cortex, temporo-occipital cortex and parietal cortex. No neuronal activation was seen within the primary motor cortex (at sites previously shown to be associated with volitional breathing). 5. These results suggest neuronal activation within the limbic system; this activation may be important in the sensory and/or motor respiratory responses to hypercapnia in awake man.
Keywords
Adult, Carbon Dioxide/physiology, Cerebrovascular Circulation/physiology, Humans, Limbic System/blood supply, Limbic System/physiology, Male, Middle Aged, Respiration/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 19:34
Last modification date
20/08/2019 14:54
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