Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_90766E9A9F26
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.
Journal
Aging
Author(s)
Fiorito G., McCrory C., Robinson O., Carmeli C., Rosales C.O., Zhang Y., Colicino E., Dugué P.A., Artaud F., McKay G.J., Jeong A., Mishra P.P., Nøst T.H., Krogh V., Panico S., Sacerdote C., Tumino R., Palli D., Matullo G., Guarrera S., Gandini M., Bochud M., Dermitzakis E., Muka T., Schwartz J., Vokonas P.S., Just A., Hodge A.M., Giles G.G., Southey M.C., Hurme M.A., Young I., McKnight A.J., Kunze S., Waldenberger M., Peters A., Schwettmann L., Lund E., Baccarelli A., Milne R.L., Kenny R.A., Elbaz A., Brenner H., Kee F., Voortman T., Probst-Hensch N., Lehtimäki T., Elliot P., Stringhini S., Vineis P., Polidoro S.
Working group(s)
BIOS Consortium, Lifepath consortium
ISSN
1945-4589 (Electronic)
ISSN-L
1945-4589
Publication state
Published
Issued date
14/04/2019
Peer-reviewed
Oui
Volume
11
Number
7
Pages
2045-2070
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect.Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity.
Keywords
Aged, Aging/genetics, Aging/psychology, Cohort Studies, DNA Methylation, Educational Status, Epigenesis, Genetic, Female, Humans, Life Style, Male, Mutation, Risk Factors, Social Class, biological aging, education, epigenetic clocks, socioeconomic position
Pubmed
Web of science
Create date
03/05/2019 17:31
Last modification date
23/06/2020 6:21
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