Hypertension is an independent predictor of mean platelet volume in patients with acute ischaemic stroke.

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State: Public
Version: author
Serval ID
serval:BIB_900141F6D251
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hypertension is an independent predictor of mean platelet volume in patients with acute ischaemic stroke.
Journal
Internal Medicine Journal
Author(s)
Ntaios George, Gurer Ozgur, Faouzi Mohamed, Aubert Carole, Michel Patrik
ISSN
1445-5994 (Electronic)
ISSN-L
1444-0903
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
41
Number
9
Pages
691-695
Language
english
Abstract
Introduction: Mean platelet volume (MPV) was shown to be significantly increased in patients with acute ischaemic stroke, especially in non-lacunar strokes. Moreover, some studies concluded that increased MPV is related to poor functional outcome after ischaemic stroke, although this association is still controversial. However, the determinants of MPV in patients with acute ischaemic stroke have never been investigated. Subjects and methods: We recorded the main demographic, clinical and laboratory data of consecutive patients with acute (admitted within 24 h after stroke onset) ischaemic stroke admitted in our Neurology Service between January 2003 and December 2008. MPV was generated at admission by the Sysmex XE-2100 automated cell counter (Sysmex Corporation, Kobe, Japan) from ethylenediaminetetraacetic acid blood samples stored at room temperature until measurement. The association of these parameters with MPV was investigated in univariate and multivariate analysis. Results: A total of 636 patients was included in our study. The median MPV was 10.4 ± 0.82 fL. In univariate analysis, glucose (β= 0.03, P= 0.05), serum creatinine (β= 0.002, P= 0.02), haemoglobin (β= 0.009, P < 0.001), platelet count (β=-0.002, P < 0.001) and history of arterial hypertension (β= 0.21, P= 0.005) were found to be significantly associated with MPV. In multivariate robust regression analysis, only hypertension and platelet count remained as independent determinants of MPV. Conclusions: In patients with acute ischaemic stroke, platelet count and history of hypertension are the only determinants of MPV.
Pubmed
Web of science
Create date
09/09/2011 15:31
Last modification date
20/08/2019 15:53
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