Weight cycling per se, independently of excess weight gain, promotes fat accumulation and insulin resistance

Details

Serval ID
serval:BIB_8F6B686F006A
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Title
Weight cycling per se, independently of excess weight gain, promotes fat accumulation and insulin resistance
Title of the conference
International Journal of Obesity
Author(s)
Prevot A, Dulloo A, Montani JP
Organization
3rd Fribourg Obesity Research Conference (FORC-2005)
Address
Fribourg, SWITZERLAND, SEP 30, 2005
ISBN
0307-0565
Publication state
Published
Issued date
12/2006
Volume
30
Pages
S69
Language
english
Abstract
Many obese adults and adolescents undergo repeated cycles of dietinduced weight loss and gain, a phenomenon known as weight cycling (WC). Epidemiological studies suggest an implication of WC in increased cardiovascular morbidity/mortality. The aim of our study was to establish a rat model of WC to further evaluate its consequences on metabolic and cardiovascular diseases. Experiments were performed in male Sprague Dawley rats, initially fed with normal chow (NC 4.5% fat) for 24 days (d). Time control group I received a fixed amount of 21 g/d. Group II received the same total amount given as cycles of 3 d at -33% (14 g/d) and 3 d at +33% (28 g/d) for a total of 4 cycles. Thereafter, following a 4-d stabilization period at 21 g/d of NC, animals were switched for 14 additional days to 20 g/d of a high fat diet (23.6% fat), an amount isocaloric to 28 g of NC. At the end, a glucose tolerance test (GTT) was performed with determination of plasma glucose and insulin. Visceral fat (retroperitoneal and epididymal) was weighed and total body composition was assessed by the Soxhlet method. Despite similar body weight gain (165.8 ± 3.8 vs. 173.3 ± 2.7 g) in both groups, total body fat and visceral fat were significantly increased in cycling rats (55.6 ± 2.2 vs. 48.6 ± 1.3 g; 16.9 ± 0.8 vs. 13.9 ± 0.5 g). Cycling rats also showed a higher 30-min insulinemic response during the GTT (insulin change from baseline 6.1 ± 1.0 vs. 4.3 ± 0.9 ng/mL). Our data suggest that WC, independently of excess food intake and weight gain, may predispose to the development of cardiovascular diseases by promoting total fat and visceral fat accumulation, as well as insulin resistance.
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Create date
20/07/2009 13:52
Last modification date
20/08/2019 14:53
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