Glomerular hyperfiltration and increased proximal sodium reabsorption in subjects with type 2 diabetes or impaired fasting glucose in a population of the African region.

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Ressource 1Download: serval:BIB_8F0FAE77FCA2.P001 (615.19 [Ko])
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Serval ID
serval:BIB_8F0FAE77FCA2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Glomerular hyperfiltration and increased proximal sodium reabsorption in subjects with type 2 diabetes or impaired fasting glucose in a population of the African region.
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Pruijm M., Wuerzner G., Maillard M., Bovet P., Renaud C., Bochud M., Burnier M.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
25
Number
7
Pages
2225-2231
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND. Glomerular hyperfiltration (GHF) is a well-recognized early renal alteration in diabetic patients. As the prevalence of GHF is largely unknown in populations in the African region with respect to normal fasting glucose (NFG), impaired fasting glucose (IFG) and type 2 diabetes [diabetes mellitus (DM)], we conducted a cross-sectional study in the Seychelles islands among families including at least one member with hypertension. METHODS. The glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and proximal tubular sodium reabsorption were measured using inulin, p-aminohippurate (PAH) and endogenous lithium clearance, respectively. Twenty-four-hour urine was collected on the preceding day. RESULTS. Of the 363 participants (mean age 44.7 years), 6.6% had IFG, 9.9% had DM and 63.3% had hypertension. The prevalence of GHF, defined as a GFR >140 ml/min, was 17.2%, 29.2% and 52.8% in NFG, IFG and DM, respectively (P trend <0.001). Compared to NFG, the adjusted odds ratio for GHF was 1.99 [95% confidence interval (CI) 0.73-5.44] for IFG and 5.88 (2.39-14.45) for DM. Lithium clearance and fractional excretion of lithium were lower in DM and IFG than NFG (P < 0.001). CONCLUSION. In this population of African descent, subjects with impaired fasting glucose or type 2 diabetes had a high prevalence of GHF and enhanced proximal sodium reabsorption. These findings provide further insight on the elevated incidence of nephropathy reported among African diabetic individuals.
Keywords
Absorption/physiology, Adult, Blood Glucose/metabolism, Cross-Sectional Studies, Diabetes Mellitus, Type 2/metabolism, Diabetes Mellitus, Type 2/physiopathology, Diabetic Nephropathies/metabolism, Diabetic Nephropathies/physiopathology, Fasting/physiology, Female, Glomerular Filtration Rate/physiology, Humans, Hypertension/metabolism, Hypertension/physiopathology, Inulin/urine, Kidney Tubules, Proximal/physiopathology, Lithium/urine, Male, Middle Aged, Prevalence, Seychelles, Sodium/metabolism, p-Aminohippuric Acid/urine
Pubmed
Web of science
Open Access
Yes
Create date
09/07/2010 16:40
Last modification date
25/09/2019 7:09
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