Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla.

Details

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_8F0AA67F9966
Type
Article: article from journal or magazin.
Collection
Publications
Title
Characterization of perfluorocarbon relaxation times and their influence on the optimization of fluorine-19 MRI at 3 tesla.
Journal
Magnetic resonance in medicine
Author(s)
Colotti R., Bastiaansen JAM, Wilson A., Flögel U., Gonzales C., Schwitter J., Stuber M., van Heeswijk R.B.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
06/2017
Peer-reviewed
Oui
Volume
77
Number
6
Pages
2263-2271
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article
Publication Status: ppublish
Abstract
To characterize and optimize javax.xml.bind.JAXBElement@7524a985 F MRI for different perfluorocarbons (PFCs) at 3T and quantify the loss of acquisition efficiency as a function of different temperature and cellular conditions.
The T javax.xml.bind.JAXBElement@1ef4ca84 and T javax.xml.bind.JAXBElement@295b7e6f relaxation times of the commonly used PFCs perfluoropolyether (PFPE), perfluoro-15-crown-5-ether (PFCE), and perfluorooctyl bromide (PFOB) were measured in phantoms and in several different conditions (cell types, presence of fixation agent, and temperatures). These relaxation times were used to optimize pulse sequences through numerical simulations. The acquisition efficiency in each cellular condition was then determined as the ratio of the signal after optimization with the reference relaxation times and after optimization with its proper relaxation times. Finally, PFC detection limits were determined.
The loss of acquisition efficiency due to parameter settings optimized for the wrong temperature and cellular condition was limited to 13%. The detection limits of all PFCs were lower at 24 °C than at 37 °C and varied from 11.8 ± 3.0 mM for PFCE at 24 °C to 379.9 ± 51.8 mM for PFOB at 37 °C.
Optimizing javax.xml.bind.JAXBElement@30187e57 F pulse sequences with a known phantom only leads to moderate loss in acquisition efficiency in cellular conditions that might be encountered in in vivo and in vitro experiments. Magn Reson Med 77:2263-2271, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Keywords
Crown Ethers/chemistry, Ethers/chemistry, Fluorine/chemistry, Fluorocarbons/chemistry, Image Enhancement/methods, Image Interpretation, Computer-Assisted/methods, Magnetic Resonance Imaging/instrumentation, Magnetic Resonance Imaging/methods, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, balanced steady-state free precession, detection limit, fluorine MRI, perfluorocarbon, pulse sequence optimization, turbo spin echo
Pubmed
Web of science
Open Access
Yes
Create date
19/07/2016 19:12
Last modification date
20/08/2019 15:52
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