Prefrontal cortex development and emergence of self-regulatory competence: the two cardinal features of adolescence disrupted in context of alcohol abuse.

Details

Serval ID
serval:BIB_8EF2DE112415
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prefrontal cortex development and emergence of self-regulatory competence: the two cardinal features of adolescence disrupted in context of alcohol abuse.
Journal
The European journal of neuroscience
Author(s)
Jadhav K.S., Boutrel B.
ISSN
1460-9568 (Electronic)
ISSN-L
0953-816X
Publication state
Published
Issued date
08/2019
Peer-reviewed
Oui
Volume
50
Number
3
Pages
2274-2281
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Adolescence is a tumultuous period in the lifetime of an individual confronted to major changes in emotional, social and cognitive appraisal. During this period of questioning and doubt, while the executive functions are still maturing, the abstract reasoning remains vague and the response inhibition loose; ultimately the adolescent scarcely resists temptation. Consequently, adolescence is often associated with uninhibited risk-taking, reckless behaviours, among which are alcohol and illicit drugs use. Here, we discuss how the development of the prefrontal cortex (which critically contributes to rational decision-making and temporal processing of complex events) can be associated with the idiosyncratic adolescent behaviour, and potentially uncontrolled alcohol use. Most importantly, we present clinical and preclinical evidence supporting that ethanol exposure has deleterious effects on the adolescent developing brain. Ultimately, we discuss why a late maturing prefrontal cortex represents a ripe candidate to environmental influences that contribute to shape the adolescent brain but, potentially, can also trigger lifelong maladaptive responses, including increased vulnerability to develop substance use disorder later in life.
Keywords
Adolescent, Adolescent Behavior/physiology, Adolescent Behavior/psychology, Alcoholism/diagnosis, Alcoholism/psychology, Animals, Ethanol/administration & dosage, Ethanol/toxicity, Humans, Prefrontal Cortex/drug effects, Prefrontal Cortex/growth & development, Self-Control/psychology, Underage Drinking/psychology, Underage Drinking/trends, addiction, adolescence, alcohol, binge drinking, prefrontal cortex
Pubmed
Web of science
Create date
10/01/2019 11:22
Last modification date
18/08/2020 6:21
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