Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study.

Details

Serval ID
serval:BIB_8EEF7FDA7F91
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study.
Journal
Transplant international
Author(s)
Schreiber P.W., Bischoff-Ferrari H.A., Boggian K., van Delden C., Enriquez N., Fehr T., Garzoni C., Hirsch H.H., Hirzel C., Manuel O., Meylan P., Saleh L., Weisser M., Mueller N.J.
Working group(s)
Swiss Transplant Cohort Study (STCS)
Contributor(s)
Amico P., Aubert J.D., Banz V., Beldi G., Benden C., Berger C., Binet I., Bochud P.Y., Boëly E., Bucher H., Carell T., Catana E., Chalandon Y., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Ferrari-Lacraz S., Soccal P.G., Gaudet C., Giostra E., Golshayan D., Hadaya K., Halter J., Heim D., Hess C., Hillinger S., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Koller M., Laesser B., Lehmann R., Lovis C., Majno P., Marti H.P., Martin P.Y., Mohacsi P., Morel P., Mueller U., Mueller-McKenna H., Müller A., Müller T., Müllhaupt B., Pascual M., Passweg J., Posfay-Barbe K., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Schnyder A., Seiler C., Sprachta J., Stampf S., Steiger J., Stirnimann G., Toso C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1432-2277 (Electronic)
ISSN-L
0934-0874
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
32
Number
1
Pages
49-58
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency [25-OH vitamin D (25-OHD) <50 nmol/l] and no deficiency (25-OHD ≥50 nmol/l) in incident infections after liver transplantation. In 135 liver transplant recipients, blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the Swiss Transplant Cohort Study database. Poisson regression was applied to address associations between vitamin D status and incident infections. Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses, vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant incidence rate ratio (IRR 1.52, 95% CI 1.08-2.15, P = 0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P = 0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections.
Keywords
Adult, Aged, Bacterial Infections/epidemiology, Female, Humans, Liver Failure/blood, Liver Failure/surgery, Liver Transplantation/adverse effects, Male, Middle Aged, Multivariate Analysis, Poisson Distribution, Postoperative Complications, Prospective Studies, Regression Analysis, Risk Factors, Switzerland, Vitamin D/blood, Vitamin D Deficiency/complications, infections, liver transplantation, post-transplant care, vitamin D
Pubmed
Web of science
Create date
20/08/2018 14:09
Last modification date
20/08/2019 15:52
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