Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.

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Version: Final published version
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Serval ID
serval:BIB_8EBC6CB579E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.
Journal
Cancer immunology, immunotherapy : CII
Author(s)
Hoeller C., Michielin O., Ascierto P.A., Szabo Z., Blank C.U.
ISSN
1432-0851 (Electronic)
ISSN-L
0340-7004
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
65
Number
9
Pages
1015-1034
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Several immunomodulatory checkpoint inhibitors have been approved for the treatment of patients with advanced melanoma, including ipilimumab, nivolumab and pembrolizumab. Talimogene laherparepvec is the first oncolytic virus to gain regulatory approval in the USA; it is also approved in Europe. Talimogene laherparepvec expresses granulocyte-macrophage colony-stimulating factor (GM-CSF), and with other GM-CSF-expressing oncolytic viruses in development, understanding the clinical relevance of this cytokine in treating advanced melanoma is important. Results of trials of GM-CSF in melanoma have been mixed, and while GM-CSF has the potential to promote anti-tumor responses, some preclinical data suggest that GM-CSF may sometimes promote tumor growth. GM-CSF has not been approved as a melanoma treatment. We undertook a systematic literature review of studies of GM-CSF in patients with advanced melanoma (stage IIIB-IV). Of the 503 articles identified, 26 studies met the eligibility criteria. Most studies investigated the use of GM-CSF in combination with another treatment, such as peptide vaccines or chemotherapy, or as an adjuvant to surgery. Some clinical benefit was reported in patients who received GM-CSF as an adjuvant to surgery, or in combination with other treatments. In general, outcomes for patients receiving peptide vaccines were not improved with the addition of GM-CSF. GM-CSF may be a valuable therapeutic adjuvant; however, further studies are needed, particularly head-to-head comparisons, to confirm the optimal dosing regimen and clinical effectiveness in patients with advanced melanoma.
Pubmed
Open Access
Yes
Create date
07/07/2016 14:18
Last modification date
07/04/2021 6:34
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