Genetic loci for retinal arteriolar microcirculation.
Details
Serval ID
serval:BIB_8E9B6F79BB0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic loci for retinal arteriolar microcirculation.
Journal
Plos One
Working group(s)
Wellcome Trust Case Control Consortium 2, Global BPGen Consortium
Contributor(s)
Donnelly P., Barroso I., Blackwell J.M., Bramon E., Brown M.A., Casas J.P., Corvin A., Deloukas P., Duncanson A., Jankowski J., Markus H.S., Mathew C.G., Palmer C.N., Plomin R., Rautanen A., Sawcer S.J., Trembath R.C., Viswanathan A.C., Wood N.W., Spencer C.C., Band G., Bellenguez C., Freeman C., Hellenthal G., Giannoulatou E., Pirinen M., Pearson R., Strange A., Su Z., Vukcevic D., Donnelly P., Langford C., Hunt S.E., Edkins S., Gwilliam R., Blackburn H., Bumpstead S.J., Dronov S., Gillman M., Gray E., Hammond N., Jayakumar A., McCann O.T., Liddle J., Potter S.C., Ravindrarajah R., Ricketts M., Waller M., Weston P., Widaa S., Whittaker P., Barroso I., Deloukas P., Mathew C., Blackwell J.M., Brown M.A., Corvin A., McCarthy M.I., Spencer C.C., Newton-Cheh C., Johnson T., Gateva V., Tobin M.D., Bochud M., Coin L., Najjar S.S., Zhao J.H., Heath S.C., Eyheramendy S., Papadakis K., Voight B.F., Scott L.J., Zhang F., Farrall M., Tanaka T., Wallace C., Chambers J.C., Khaw K.T., Nilsson P., van der Harst P., Polidoro S., Grobbee D.E., Onland-Moret N.C., Bots M.L., Wain L.V., Elliott K.S., Teumer A., Luan J.J., Lucas G., Kuusisto J., Burton P.R., Hadley D., McArdle W.L., Brown M., Dominiczak A., Newhouse S.J., Samani N.J., Webster J., Zeggini E., Beckmann J.S., Bergmann S., Lim N., Song K., Vollenweider P., Waeber G., Waterworth D.M., Yuan X., Groop L., Orho-Melander M., Allione A., Di Gregorio A., Guarrera S., Panico S., Ricceri F., Romanazzi V., Sacerdote C., Vineis P., Barroso I., Sandhu M.S., Luben R.N., Crawford G.J., Jousilahti P., Perola M., Boehnke M., Bonnycastle L.L., Collins F.S., Jackson A.U., Mohlke K.L., Stringham H.M., Valle T.T., Willer C.J., Bergman R.N., Morken M.A., Döring A., Gieger C., Illig T., Meitinger T., Org E., Pfeufer A., Wichmann H.E., Kathiresan S., Marrugat J., O'Donnell C.J., Schwartz S.M., Siscovick D.S., Subirana I., Freimer N.B., Hartikainen A.L., McCarthy M.I., O'Reilly P.F., Peltonen L., Pouta A., de Jong P.E., Snieder H., van Gilst W.H., Clarke R., Goel A., Hamsten A., Peden J.F., Seedorf U., Syvänen A.C., Tognoni G., Lakatta E.G., Sanna S., Scheet P., Schlessinger D., Scuteri A., Dörr M., Ernst F., Felix S.B., Homuth G., Lorbeer R., Reffelmann T., Rettig R., Völker U., Galan P., Gut I.G., Hercberg S., Lathrop G.M., Zeleneka D., Deloukas P., Soranzo N., Williams F.M., Zhai G., Salomaa V., Laakso M., Elosua R., Forouhi N.G., Völzke H., Uiterwaal C.S., van der Schouw Y.T., Numans M.E., Matullo G., Navis G., Berglund G., Bingham S.A., Kooner J.S., Connell J.M., Bandinelli S., Ferrucci L., Watkins H., Spector T.D., Tuomilehto J., Altshuler D., Strachan D.P., Laan M., Meneton P., Wareham N.J., Uda M., Jarvelin M.R., Mooser V., Melander O., Loos R.J., Elliott P., Abecasis G.R., Caulfield M., Munroe P.B.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2013
Volume
8
Number
6
Pages
e65804
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value <5×10(-8). This variant was replicated in an additional 3,939 individuals of European ancestry from the Australian Twins Study and Multi-Ethnic Study of Atherosclerosis (rs2194025, P-value = 2.11×10(-12) in combined meta-analysis of discovery and replication cohorts). In independent studies of modest sample sizes, no significant association was found between this variant and clinical outcomes including coronary artery disease, stroke, myocardial infarction or hypertension. In conclusion, we found one novel loci which underlie genetic variation in microvasculature which may be relevant to vascular disease. The relevance of these findings to clinical outcomes remains to be determined.
Pubmed
Web of science
Open Access
Yes
Create date
16/01/2014 14:55
Last modification date
20/08/2019 14:52
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