Regards recents sur la barriere hemato-encephalique. [The blood-brain barrier: recent insights]

Details

Serval ID
serval:BIB_8E8C04B12557
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Regards recents sur la barriere hemato-encephalique. [The blood-brain barrier: recent insights]
Journal
Revue Médicale Suisse
Author(s)
Buclin  T., Biollaz  J.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
04/2005
Volume
1
Number
14
Pages
959-63
Notes
English Abstract
Journal Article
Review --- Old month value: Apr 6
Abstract
The blood-brain barrier must not be regarded as a purely passive wall opposing low permeability to undesirable compounds circulating in blood. It limits the access of molecules to brain tissue by a joint interplay of cerebro-spinal fluid turnover and selective uptake and expulsion of compounds through active drug carriers. The inhibition of such transporters can increase brain penetration of substrates leading to drug interactions with neuropsychiatric manifestations; it can also be exploited to increase brain and CSF concentrations of anti-infective, anti-neoplastic or psychotropic agents. Genetic polymorphisms affecting transporters may modulate the brain exposure to drugs in selected individuals. Such observations improve our understanding of a key mechanism governing clinical neuro-psychopharmacology.
Keywords
Animals Blood-Brain Barrier/*physiology Humans P-Glycoprotein/physiology
Pubmed
Create date
25/01/2008 11:40
Last modification date
03/03/2018 19:18
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