Médecine de précision dans le traitement des cancers pédiatriques [Precision medicine in the treatment of pediatric cancers]
Details
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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_8E7BBA220C93
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Médecine de précision dans le traitement des cancers pédiatriques [Precision medicine in the treatment of pediatric cancers]
Journal
Revue medicale suisse
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
22/02/2023
Peer-reviewed
Oui
Volume
19
Number
815
Pages
380-387
Language
french
Notes
Publication types: Review ; English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Despite the progress in cure rates for pediatric cancers, several challenges remain, such as the management of diseases with poor prognosis. The efficacy of intensified chemotherapies is also accompanied by increased risks of severe acute and chronic toxicities. Thus, therapies specifically targeting tumor cells, or inhibiting oncogenic molecular aberrations, could provide more effective and less toxic treatments for pediatric cancers. Personalization of chemotherapies through pharmacogenetics and precision dosing could also improve the efficacy and toxicity of chemotherapies. In this review, we describe precision medicine strategies implemented or undergoing clinical evaluation in the treatment of pediatric cancers.
Keywords
Child, Humans, Precision Medicine, Neoplasms/drug therapy, Pharmacogenetics, Molecular Targeted Therapy
Pubmed
Create date
03/03/2023 17:21
Last modification date
22/08/2023 7:13