The weaker points of fish acute toxicity tests and how tests on embryos can solve some issues.

Details

Serval ID
serval:BIB_8E675341770C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The weaker points of fish acute toxicity tests and how tests on embryos can solve some issues.
Journal
Environmental Pollution
Author(s)
Wedekind C., von Siebenthal B., Gingold R.
ISSN
0269-7491 (Print)
ISSN-L
0269-7491
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
148
Number
2
Pages
385-389
Language
english
Abstract
Fish acute toxicity tests play an important role in environmental risk assessment and hazard classification because they allow for first estimates of the relative toxicity of various chemicals in various species. However, such tests need to be carefully interpreted. Here we shortly summarize the main issues which are linked to the genetics and the condition of the test animals, the standardized test situations, the uncertainty about whether a given test species can be seen as representative to a given fish fauna, the often missing knowledge about possible interaction effects, especially with micropathogens, and statistical problems like small sample sizes and, in some cases, pseudoreplication. We suggest that multi-factorial embryo tests on ecologically relevant species solve many of these issues, and we shortly explain how such tests could be done to avoid the weaker points of fish acute toxicity tests.
Keywords
Animals, Embryo, Nonmammalian/drug effects, Fishes/embryology, Fishes/genetics, Guidelines as Topic, Host-Parasite Interactions, Risk Assessment/methods, Sample Size, Species Specificity, Toxicity Tests, Acute/methods
Pubmed
Web of science
Create date
25/01/2008 11:43
Last modification date
20/08/2019 15:52
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