Mild Depressive Symptoms Mediate the Impact of Childhood Trauma on Long-Term Functional Outcome in Early Psychosis Patients.

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Serval ID
serval:BIB_8E2ACCB12E6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mild Depressive Symptoms Mediate the Impact of Childhood Trauma on Long-Term Functional Outcome in Early Psychosis Patients.
Journal
Schizophrenia bulletin
Author(s)
Alameda L. (co-first), Golay P. (co-first), Baumann P.S., Progin P., Mebdouhi N., Elowe J., Ferrari C., Do K.Q., Conus P.
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Publication state
Published
Issued date
01/09/2017
Peer-reviewed
Oui
Volume
43
Number
5
Pages
1027-1035
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The mechanism linking childhood trauma (CT) to the functional deficits observed in early psychosis (EP) patients is as yet unknown. We aim to examine the potential mediating effect of depressive symptoms in this well-established association.
Two hundred nine EP subjects aged 18-35 were assessed for functioning and psychopathology after 2, 6, 12, 18, 24, 30, and 36 months of treatment. Patients were classified into early trauma if they had faced at least one experience of abuse (physical, sexual, or emotional) or neglect (physical or emotional) before age 12, and late trauma if the exposure had occurred between ages 12 and 16. Diagnosis was based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). Psychopathology was assessed with the Positive and Negative Syndrome Scale and the Montgomery-Asberg Depression Rating Scale. Functioning was measured with the Global Assessment of Functioning (GAF) and the Social and Occupational Functioning Assessment Scale (SOFAS). Mediation analyses were performed in order to study whether the relationship between CT and functioning was mediated by depressive symptoms.
When compared with nonexposed patients, early but not late trauma patients showed lower levels of GAF and SOFAS scores over all the time points, excepting after the first assessment. After 30 and 36 months, the effect of early trauma on functioning was completely mediated by depressive symptoms. No mediating effect of positive or negative symptoms was highlighted at those time points.
Mild depressive symptoms mediated the impact of early trauma on long-term functional outcome. Intensifying pharmacologic and/or psychotherapeutic treatment, focused on the depressive dimension, may help traumatized EP patients to improve their functioning.
Keywords
Adolescent, Adult, Adult Survivors of Child Adverse Events/statistics & numerical data, Age Factors, Comorbidity, Depression/epidemiology, Depression/physiopathology, Depression/therapy, Female, Follow-Up Studies, Humans, Male, Outcome Assessment (Health Care), Psychotic Disorders/epidemiology, Psychotic Disorders/physiopathology, Psychotic Disorders/therapy, Young Adult, childhood trauma, depression, first episode psychosis, functional outcome, mediation, prospective, psychopathology
Pubmed
Web of science
Open Access
Yes
Create date
31/10/2016 15:40
Last modification date
13/01/2021 20:35
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