Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

Patel, Y.; Parker, N.; Shin, J.; Howard, D.; French, L.; Thomopoulos, S.I.; Pozzi, E.; Abe, Y.; Abé, C.; Anticevic, A.; Alda, M.; Aleman, A.; Alloza, C.; Alonso-Lana, S.; Ameis, S.H.; Anagnostou, E.; McIntosh, A.A.; Arango, C.; Arnold, P.D.; Asherson, P.; Assogna, F.; Auzias, G.; Ayesa-Arriola, R.; Bakker, G.; Banaj, N.; Banaschewski, T.; Bandeira, C.E.; Baranov, A.; Bargalló, N.; Bau, CHD; Baumeister, S.; Baune, B.T.; Bellgrove, M.A.; Benedetti, F.; Bertolino, A.; Boedhoe, PSW; Boks, M.; Bollettini, I.; Del Mar Bonnin, C.; Borgers, T.; Borgwardt, S.; Brandeis, D.; Brennan, B.P.; Bruggemann, J.M.; Bülow, R.; Busatto, G.F.; Calderoni, S.; Calhoun, V.D.; Calvo, R.; Canales-Rodríguez, E.J.; Cannon, D.M.; Carr, V.J.; Cascella, N.; Cercignani, M.; Chaim-Avancini, T.M.; Christakou, A.; Coghill, D.; Conzelmann, A.; Crespo-Facorro, B.; Cubillo, A.I.; Cullen, K.R.; Cupertino, R.B.; Daly, E.; Dannlowski, U.; Davey, C.G.; Denys, D.; Deruelle, C.; Di Giorgio, A.; Dickie, E.W.; Dima, D.; Dohm, K.; Ehrlich, S.; Ely, B.A.; Erwin-Grabner, T.; Ethofer, T.; Fair, D.A.; Fallgatter, A.J.; Faraone, S.V.; Fatjó-Vilas, M.; Fedor, J.M.; Fitzgerald, K.D.; Ford, J.M.; Frodl, T.; Fu, CHY; Fullerton, J.M.; Gabel, M.C.; Glahn, D.C.; Roberts, G.; Gogberashvili, T.; Goikolea, J.M.; Gotlib, I.H.; Goya-Maldonado, R.; Grabe, H.J.; Green, M.J.; Grevet, E.H.; Groenewold, N.A.; Grotegerd, D.; Gruber, O.; Gruner, P.; Guerrero-Pedraza, A.; Gur, R.E.; Gur, R.C.; Haar, S.; Haarman, BCM; Haavik, J.; Hahn, T.; Hajek, T.; Harrison, B.J.; Harrison, N.A.; Hartman, C.A.; Whalley, H.C.; Heslenfeld, D.J.; Hibar, D.P.; Hilland, E.; Hirano, Y.; Ho, T.C.; Hoekstra, P.J.; Hoekstra, L.; Hohmann, S.; Hong, L.E.; Höschl, C.; Høvik, M.F.; Howells, F.M.; Nenadic, I.; Jalbrzikowski, M.; James, A.C.; Janssen, J.; Jaspers-Fayer, F.; Xu, J.; Jonassen, R.; Karkashadze, G.; King, J.A.; Kircher, T.; Kirschner, M.; Koch, K.; Kochunov, P.; Kohls, G.; Konrad, K.; Krämer, B.; Krug, A.; Kuntsi, J.; Kwon, J.S.; Landén, M.; Landrø, N.I.; Lazaro, L.; Lebedeva, I.S.; Leehr, E.J.; Lera-Miguel, S.; Lesch, K.P.; Lochner, C.; Louza, M.R.; Luna, B.; Lundervold, A.J.; MacMaster, F.P.; Maglanoc, L.A.; Malpas, C.B.; Portella, M.J.; Marsh, R.; Martyn, F.M.; Mataix-Cols, D.; Mathalon, D.H.; McCarthy, H.; McDonald, C.; McPhilemy, G.; Meinert, S.; Menchón, J.M.; Minuzzi, L.; Mitchell, P.B.; Moreno, C.; Morgado, P.; Muratori, F.; Murphy, C.M.; Murphy, D.; Mwangi, B.; Nabulsi, L.; Nakagawa, A.; Nakamae, T.; Namazova, L.; Narayanaswamy, J.; Jahanshad, N.; Nguyen, D.D.; Nicolau, R.; O'Gorman Tuura, R.L.; O'Hearn, K.; Oosterlaan, J.; Opel, N.; Ophoff, R.A.; Oranje, B.; García de la Foz, V.O.; Overs, B.J.; Paloyelis, Y.; Pantelis, C.; Parellada, M.; Pauli, P.; Picó-Pérez, M.; Picon, F.A.; Piras, F.; Piras, F.; Plessen, K.J.; Pomarol-Clotet, E.; Preda, A.; Puig, O.; Quidé, Y.; Radua, J.; Ramos-Quiroga, J.A.; Rasser, P.E.; Rauer, L.; Reddy, J.; Redlich, R.; Reif, A.; Reneman, L.; Repple, J.; Retico, A.; Richarte, V.; Richter, A.; Rosa, PGP; Rubia, K.K.; Hashimoto, R.; Sacchet, M.D.; Salvador, R.; Santonja, J.; Sarink, K.; Sarró, S.; Satterthwaite, T.D.; Sawa, A.; Schall, U.; Schofield, P.R.; Schrantee, A.; Seitz, J.; Serpa, M.H.; Setién-Suero, E.; Shaw, P.; Shook, D.; Silk, T.J.; Sim, K.; Simon, S.; Simpson, H.B.; Singh, A.; Skoch, A.; Skokauskas, N.; Soares, J.C.; Soreni, N.; Soriano-Mas, C.; Spalletta, G.; Spaniel, F.; Lawrie, S.M.; Stern, E.R.; Stewart, S.E.; Takayanagi, Y.; Temmingh, H.S.; Tolin, D.F.; Tomecek, D.; Tordesillas-Gutiérrez, D.; Tosetti, M.; Uhlmann, A.; van Amelsvoort, T.; van der Wee, NJA; van der Werff, SJA; van Haren, NEM; van Wingen, G.A.; Vance, A.; Vázquez-Bourgon, J.; Vecchio, D.; Venkatasubramanian, G.; Vieta, E.; Vilarroya, O.; Vives-Gilabert, Y.; Voineskos, A.N.; Völzke, H.; von Polier, G.G.; Walton, E.; Weickert, T.W.; Weickert, C.S.; Weideman, A.S.; Wittfeld, K.; Wolf, D.H.; Wu, M.J.; Yang, T.T.; Yang, K.; Yoncheva, Y.; Yun, J.Y.; Cheng, Y.; Zanetti, M.V.; Ziegler, G.C.; Franke, B.; Hoogman, M.; Buitelaar, J.K.; van Rooij, D.; Andreassen, O.A.; Ching, CRK; Veltman, D.J.; Schmaal, L.; Stein, D.J.; van den Heuvel, O.A.; Turner, J.A.; van Erp, TGM; Pausova, Z.; Thompson, P.M.; Paus, T.

doi:10.1001/jamapsychiatry.2020.2694

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

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Serval ID

serval:BIB_8E229AECF07C

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

Journal

JAMA psychiatry

Author(s)

Patel Y., Parker N., Shin J., Howard D., French L., Thomopoulos S.I., Pozzi E., Abe Y., Abé C., Anticevic A., Alda M., Aleman A., Alloza C., Alonso-Lana S., Ameis S.H., Anagnostou E., McIntosh A.A., Arango C., Arnold P.D., Asherson P., Assogna F., Auzias G., Ayesa-Arriola R., Bakker G., Banaj N., Banaschewski T., Bandeira C.E., Baranov A., Bargalló N., Bau CHD, Baumeister S., Baune B.T., Bellgrove M.A., Benedetti F., Bertolino A., Boedhoe PSW, Boks M., Bollettini I., Del Mar Bonnin C., Borgers T., Borgwardt S., Brandeis D., Brennan B.P., Bruggemann J.M., Bülow R., Busatto G.F., Calderoni S., Calhoun V.D., Calvo R., Canales-Rodríguez E.J., Cannon D.M., Carr V.J., Cascella N., Cercignani M., Chaim-Avancini T.M., Christakou A., Coghill D., Conzelmann A., Crespo-Facorro B., Cubillo A.I., Cullen K.R., Cupertino R.B., Daly E., Dannlowski U., Davey C.G., Denys D., Deruelle C., Di Giorgio A., Dickie E.W., Dima D., Dohm K., Ehrlich S., Ely B.A., Erwin-Grabner T., Ethofer T., Fair D.A., Fallgatter A.J., Faraone S.V., Fatjó-Vilas M., Fedor J.M., Fitzgerald K.D., Ford J.M., Frodl T., Fu CHY, Fullerton J.M., Gabel M.C., Glahn D.C., Roberts G., Gogberashvili T., Goikolea J.M., Gotlib I.H., Goya-Maldonado R., Grabe H.J., Green M.J., Grevet E.H., Groenewold N.A., Grotegerd D., Gruber O., Gruner P., Guerrero-Pedraza A., Gur R.E., Gur R.C., Haar S., Haarman BCM, Haavik J., Hahn T., Hajek T., Harrison B.J., Harrison N.A., Hartman C.A., Whalley H.C., Heslenfeld D.J., Hibar D.P., Hilland E., Hirano Y., Ho T.C., Hoekstra P.J., Hoekstra L., Hohmann S., Hong L.E., Höschl C., Høvik M.F., Howells F.M., Nenadic I., Jalbrzikowski M., James A.C., Janssen J., Jaspers-Fayer F., Xu J., Jonassen R., Karkashadze G., King J.A., Kircher T., Kirschner M., Koch K., Kochunov P., Kohls G., Konrad K., Krämer B., Krug A., Kuntsi J., Kwon J.S., Landén M., Landrø N.I., Lazaro L., Lebedeva I.S., Leehr E.J., Lera-Miguel S., Lesch K.P., Lochner C., Louza M.R., Luna B., Lundervold A.J., MacMaster F.P., Maglanoc L.A., Malpas C.B., Portella M.J., Marsh R., Martyn F.M., Mataix-Cols D., Mathalon D.H., McCarthy H., McDonald C., McPhilemy G., Meinert S., Menchón J.M., Minuzzi L., Mitchell P.B., Moreno C., Morgado P., Muratori F., Murphy C.M., Murphy D., Mwangi B., Nabulsi L., Nakagawa A., Nakamae T., Namazova L., Narayanaswamy J., Jahanshad N., Nguyen D.D., Nicolau R., O'Gorman Tuura R.L., O'Hearn K., Oosterlaan J., Opel N., Ophoff R.A., Oranje B., García de la Foz V.O., Overs B.J., Paloyelis Y., Pantelis C., Parellada M., Pauli P., Picó-Pérez M., Picon F.A., Piras F., Piras F., Plessen K.J., Pomarol-Clotet E., Preda A., Puig O., Quidé Y., Radua J., Ramos-Quiroga J.A., Rasser P.E., Rauer L., Reddy J., Redlich R., Reif A., Reneman L., Repple J., Retico A., Richarte V., Richter A., Rosa PGP, Rubia K.K., Hashimoto R., Sacchet M.D., Salvador R., Santonja J., Sarink K., Sarró S., Satterthwaite T.D., Sawa A., Schall U., Schofield P.R., Schrantee A., Seitz J., Serpa M.H., Setién-Suero E., Shaw P., Shook D., Silk T.J., Sim K., Simon S., Simpson H.B., Singh A., Skoch A., Skokauskas N., Soares J.C., Soreni N., Soriano-Mas C., Spalletta G., Spaniel F., Lawrie S.M., Stern E.R., Stewart S.E., Takayanagi Y., Temmingh H.S., Tolin D.F., Tomecek D., Tordesillas-Gutiérrez D., Tosetti M., Uhlmann A., van Amelsvoort T., van der Wee NJA, van der Werff SJA, van Haren NEM, van Wingen G.A., Vance A., Vázquez-Bourgon J., Vecchio D., Venkatasubramanian G., Vieta E., Vilarroya O., Vives-Gilabert Y., Voineskos A.N., Völzke H., von Polier G.G., Walton E., Weickert T.W., Weickert C.S., Weideman A.S., Wittfeld K., Wolf D.H., Wu M.J., Yang T.T., Yang K., Yoncheva Y., Yun J.Y., Cheng Y., Zanetti M.V., Ziegler G.C., Franke B., Hoogman M., Buitelaar J.K., van Rooij D., Andreassen O.A., Ching CRK, Veltman D.J., Schmaal L., Stein D.J., van den Heuvel O.A., Turner J.A., van Erp TGM, Pausova Z., Thompson P.M., Paus T.

Working group(s)

Writing Committee for the Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups

ISSN

2168-6238 (Electronic)

ISSN-L

2168-622X

Publication state

Published

Issued date

01/01/2021

Peer-reviewed

Oui

Volume

Number

Pages

47-63

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.
To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia.
Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244.
Interregional profiles of group difference in cortical thickness between cases and controls.
A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders.
In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.

OAI-PMH

oai:serval.unil.ch:BIB_8E229AECF07C

DOI

10.1001/jamapsychiatry.2020.2694

Pubmed

32857118

Web of science

000605979600009

Create date

27/01/2021 8:56

Last modification date

30/01/2021 6:26

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Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

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