TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation.

Details

Serval ID
serval:BIB_8E100BA9B454
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation.
Journal
Journal of immunology
Author(s)
Ferrero I., Mancini S.J., Grosjean F., Wilson A., Otten L., MacDonald H.R.
ISSN
0022-1767
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
177
Number
9
Pages
6038-6043
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
During thymus development, immature T cells become committed to two distinct lineages based upon expression of alphabeta or gammadelta TCR. In the alphabeta lineage, developing thymocytes progressively extinguish transcription of the TCRgamma genes by a poorly understood process known as gamma silencing. We show that alphabeta lineage thymocytes in mice lacking a functional pre-TCR undergo limited proliferation and fail to silence TCRgamma genes during development. Stimulation of pre-TCR-deficient immature thymocytes with anti-CD3 Abs does not directly down-regulate TCRgamma transcription but restores TCRgamma silencing following proliferation. Collectively our data reveal an important role for pre-TCR induced proliferation in activating the TCRgamma silencer in alphabeta lineage thymocytes, a process that may reinforce alphabeta or gammadelta lineage commitment.
Keywords
Animals, Antibodies/pharmacology, Antigens, CD3/immunology, Cell Lineage/genetics, Cell Proliferation, Gene Silencing, Mice, Receptors, Antigen, T-Cell, alpha-beta/agonists, Receptors, Antigen, T-Cell, alpha-beta/analysis, Receptors, Antigen, T-Cell, gamma-delta/agonists, Receptors, Antigen, T-Cell, gamma-delta/genetics, Silencer Elements, Transcriptional/genetics, T-Lymphocyte Subsets/drug effects, T-Lymphocyte Subsets/immunology, Thymus Gland/cytology, Thymus Gland/growth & development
Pubmed
Web of science
Create date
09/02/2010 14:13
Last modification date
20/08/2019 14:52
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