Detection of drugs in human hair using Abbott ADx, with confirmation by gas chromatography/mass spectrometry (GC/MS).

Details

Serval ID
serval:BIB_8E088B6AF469
Type
Article: article from journal or magazin.
Collection
Publications
Title
Detection of drugs in human hair using Abbott ADx, with confirmation by gas chromatography/mass spectrometry (GC/MS).
Journal
Journal of Forensic Sciences
Author(s)
Kintz P., Ludes B., Mangin P.
ISSN
0022-1198[print], 0022-1198[linking]
Publication state
Published
Issued date
1992
Volume
37
Number
1
Pages
328-331
Language
english
Abstract
The authors suggest use of the fluorescence polarization immunoassay (FPIA) technique in evaluation of chronic drug abuse using human hair. Hair was decontaminated in 5 mL of ethanol for 15 min at 37 degrees C and then incubated in 3 mL of 1M sodium hydroxide (NaOH) for 1 h at 100 degrees C. Afterwards, the aliquots were neutralized and analyzed using Abbott ADx for a negative or positive response for the following drugs: benzodiazepines, barbiturates, antidepressants, opiates, cocaine, amphetamine, and cannabis. All the positive samples were confirmed by gas chromatography/mass spectrometry (GC/MS). Only one false positive was detected (caused by interference of a phenothiazine with the antidepressants kit), clearly demonstrating the capability of ADx for toxicological screening of human hair.
Keywords
Fluorescence Polarization, Gas Chromatography-Mass Spectrometry, Hair/chemistry, Humans, Predictive Value of Tests, Reproducibility of Results, Street Drugs/analysis
Pubmed
Create date
15/10/2010 15:35
Last modification date
20/08/2019 14:51
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