Tumor-Associated Macrophages in Bladder Cancer: Biological Role, Impact on Therapeutic Response and Perspectives for Immunotherapy.

Details

Serval ID
serval:BIB_8DF2976B356C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tumor-Associated Macrophages in Bladder Cancer: Biological Role, Impact on Therapeutic Response and Perspectives for Immunotherapy.
Journal
Cancers
Author(s)
Leblond M.M., Zdimerova H., Desponds E., Verdeil G.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
21/09/2021
Peer-reviewed
Oui
Volume
13
Number
18
Pages
4712
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Tumor-associated macrophages (TAMs) are one of the most abundant infiltrating immune cells of solid tumors. Despite their possible dual role, i.e., pro- or anti-tumoral, there is considerable evidence showing that the accumulation of TAMs promotes tumor progression rather than slowing it. Several strategies are being developed and clinically tested to target these cells. Bladder cancer (BCa) is one of the most common cancers, and despite heavy treatments, including immune checkpoint inhibitors (ICIs), the overall patient survival for advanced BCa is still poor. TAMs are present in bladder tumors and play a significant role in BCa development. However, few investigations have analyzed the effect of targeting TAMs in BCa. In this review, we focus on the importance of TAMs in a cancerous bladder, their association with patient outcome and treatment efficiency as well as on how current BCa treatments impact these cells. We also report different strategies used in other cancer types to develop new immunotherapeutic strategies with the aim of improving BCa management through TAMs targeting.
Keywords
bladder cancer, macrophage-targeting immunotherapy, macrophages
Pubmed
Web of science
Open Access
Yes
Create date
04/10/2021 10:21
Last modification date
09/10/2021 5:38
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